INT276919

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Context Info
Confidence 0.35
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.32
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Stat3) signal transduction (Stat3) plasma membrane (Stat3)
nucleus (Stat3) DNA binding (Stat3) transcription factor binding (Stat3)
Anatomy Link Frequency
macrophage 2
Stat3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 70 93.20 High High
Central nervous system 1 85.60 High High
tolerance 9 78.36 Quite High
cytokine 33 77.28 Quite High
Inflammatory response 7 74.72 Quite High
Hippocampus 1 64.44 Quite High
Crohn's disease 2 14.40 Low Low
agonist 11 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
withdrawal 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Yersinia Infection 1 97.64 Very High Very High Very High
Cancer 105 93.36 High High
INFLAMMATION 80 93.20 High High
Disease 8 87.96 High High
Stroke 3 87.00 High High
Injury 13 70.84 Quite High
Metastasis 49 66.76 Quite High
Brain Tumor 2 59.92 Quite High
Colitis 12 56.60 Quite High
Lewis Lung Carcinoma 1 50.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, the TLR2/TLR6 heterodimer is involved in phosphorylation or nuclear translocation of Stat3 induced by macrophage activating lipopeptide-2 or LcrV of Yersinia pestis [28], [29].
Regulation (involved) of Phosphorylation (phosphorylation) of Stat3 in macrophage associated with yersinia infection
1) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.74 Pain Relevance 0.04
STAT3 phosphorylation continues for a prolonged period in the absence of SOCS3 [90].
Regulation (continues) of Phosphorylation (phosphorylation) of STAT3
2) Confidence 0.29 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.22 Pain Relevance 0.12
These factors were selected because they converge onto a signal transduction pathway that is critical for the survival of NSCs and involves phosphorylation of STAT3 on the serine residue and induction of the transcription factor Hes3.
Regulation (involves) of Phosphorylation (phosphorylation) of STAT3
3) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.36 Pain Relevance 0.11

General Comments

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