INT276922

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Context Info
Confidence 0.39
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.34
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Stat3) signal transduction (Stat3) plasma membrane (Stat3)
nucleus (Stat3) DNA binding (Stat3) transcription factor binding (Stat3)
Anatomy Link Frequency
nucleus 2
Stat3 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 9 66.08 Quite High
chemokine 5 53.08 Quite High
cytokine 9 52.60 Quite High
Inflammation 4 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 81 96.36 Very High Very High Very High
Metastasis 46 93.24 High High
Skin Cancer 8 92.80 High High
Lewis Lung Carcinoma 1 69.68 Quite High
Brain Tumor 1 49.60 Quite Low
Experimental Melanoma 5 26.80 Quite Low
Death 7 14.76 Low Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low
Immunotherapy Of Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results are consensually supported by the studies in which TLR4 activation inhibits phosphorylation and nucleus translocation of Stat3 [21] and activated Stat3 inhibits TLR4 signaling in return via inhibiting transcriptional or translational activity of NF-?
Positive_regulation (activation) of Localization (translocation) of Stat3 in nucleus
1) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.34 Pain Relevance 0.12

General Comments

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