INT276928

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Context Info
Confidence 0.58
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.74
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
macrophages 1
Fibroblasts 1
nucleus 1
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 5 82.76 Quite High
Inflammation 144 76.52 Quite High
cytokine 68 75.36 Quite High
fibrosis 47 75.00 Quite High
chemokine 24 59.16 Quite High
metalloproteinase 10 51.00 Quite High
agonist 4 43.64 Quite Low
Inflammatory response 13 11.00 Low Low
tolerance 18 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 25 98.30 Very High Very High Very High
Cancer 306 95.04 Very High Very High Very High
Metastasis 101 94.16 High High
Death 14 91.36 High High
Disease 14 83.80 Quite High
Experimental Arthritis 1 82.76 Quite High
INFLAMMATION 157 76.52 Quite High
Pulmonary Fibrosis 23 75.00 Quite High
Fibrosis 27 73.04 Quite High
Skin Cancer 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fibroblasts from knockout mice did not show increased collagen synthesis, but increased levels of unprocessed IL-10 and STAT3 phosphorylation.
Phosphorylation (phosphorylation) of IL-10 in Fibroblasts associated with targeted disruption
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2951918 Disease Relevance 0.54 Pain Relevance 0.29
Knockdown of TLR2 significantly attenuated the HSP60-stimulated expressions of VEGF (P<0.01), IL-10 (P<0.01), and the phosphorylation of Stat3 (P<0.01) (Fig.
Phosphorylation (phosphorylation) of IL-10
2) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.70 Pain Relevance 0.03
, IL-6, and IL-10 exclusively through TTP phosphorylation such as in murine bone marrow-derived macrophages [126].These above studies and others offer strong evidence for the p38 MAPK regulation of ARE-mRNA stability and the association with loss of TTP function.
Phosphorylation (phosphorylation) of IL-10 in macrophages
3) Confidence 0.16 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.32 Pain Relevance 0.12
Similar to IL-6 and IL-10, Pam3Cys significantly promoted the expression, phosphorylation, and nucleus translocation of Stat3 in B16 cells (Fig. 2D–F).
Phosphorylation (phosphorylation) of IL-10 in nucleus
4) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.18 Pain Relevance 0.06

General Comments

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