INT276934

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.99
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Stat3) signal transduction (Stat3) plasma membrane (Stat3)
nucleus (Stat3) DNA binding (Stat3) transcription factor binding (Stat3)
Anatomy Link Frequency
nucleus 8
Stat3 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 29 65.64 Quite High
chemokine 15 52.64 Quite High
cytokine 27 52.16 Quite High
agonist 6 35.40 Quite Low
Eae 1 32.76 Quite Low
Inflammation 13 5.00 Very Low Very Low Very Low
depression 9 5.00 Very Low Very Low Very Low
antiepileptic Drug 7 5.00 Very Low Very Low Very Low
Lamotrigine 6 5.00 Very Low Very Low Very Low
gABA 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 269 95.92 Very High Very High Very High
Metastasis 138 92.80 High High
Skin Cancer 30 92.36 High High
Adhesions 1 92.20 High High
Thyroid Neoplasm 3 70.32 Quite High
Lewis Lung Carcinoma 3 69.68 Quite High
Apoptosis 15 62.76 Quite High
Toxicity 8 50.00 Quite Low
Brain Tumor 3 49.60 Quite Low
Leukemia 9 47.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results are consensually supported by the studies in which TLR4 activation inhibits phosphorylation and nucleus translocation of Stat3 [21] and activated Stat3 inhibits TLR4 signaling in return via inhibiting transcriptional or translational activity of NF-?
Negative_regulation (inhibits) of Localization (translocation) of Stat3 in nucleus
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.34 Pain Relevance 0.12
Similar to the IL-6- plus IL-10- neutralizing Ab, the TLR2 shRNA markedly inhibited the expression, phosphorylation and nucleus translocation of Stat3, which were partially restored by rmIL-6 and rmIL-10 (Fig. 2D–F).
Negative_regulation (inhibited) of Localization (translocation) of Stat3 in nucleus
2) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.16 Pain Relevance 0
In turn, the anti-IL-6 plus IL-10 Abs partially inhibited the Pam3Cys-stimulated expression, phosphorylation and nucleus translocation of Stat3 (Fig. 2D–F).
Negative_regulation (inhibited) of Localization (translocation) of Stat3 in nucleus
3) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.15 Pain Relevance 0
This inhibition led to a decrease in the dimerisation of STAT3 and its translocation into the nucleus for transcriptional activation of many genes in a wide range of biological processes, including induction of immune response, oncogenesis, cell cycle control, development, cell adhesion, and differentiation [63].
Negative_regulation (decrease) of Localization (translocation) of STAT3 in nucleus associated with adhesions
4) Confidence 0.12 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.34 Pain Relevance 0.03

General Comments

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