INT27694

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Context Info
Confidence 0.70
First Reported 1980
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 1.52
Pain Relevance 3.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ADRA1D) plasma membrane (ADRA1D) cell-cell signaling (ADRA1D)
DNA metabolic process (ADRA1D) signal transducer activity (ADRA1D)
Anatomy Link Frequency
plasma 2
external 2
ADRA1D (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 7 100.00 Very High Very High Very High
withdrawal 5 100.00 Very High Very High Very High
gABA 2 100.00 Very High Very High Very High
noradrenaline 5 99.60 Very High Very High Very High
Somatostatin 11 99.42 Very High Very High Very High
Hyperalgesia 1 99.38 Very High Very High Very High
Clonidine 9 99.14 Very High Very High Very High
Inflammation 7 98.94 Very High Very High Very High
tetrodotoxin 2 95.00 High High
Ventral tegmentum 4 93.44 High High
Disease Link Frequency Relevance Heat
Opiate Addiction 3 100.00 Very High Very High Very High
Hyperalgesia 1 99.38 Very High Very High Very High
Muscular Spasm 2 99.12 Very High Very High Very High
INFLAMMATION 3 98.94 Very High Very High Very High
Inflammatory Bowel Disease 3 95.44 Very High Very High Very High
Sleep Disorders 1 89.20 High High
Disease 4 86.96 High High
Organ Transplantation 2 75.00 Quite High
Stress Incontinence 2 51.04 Quite High
Increased Venous Pressure Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased alpha-adrenoceptor activation is a key candidate for the spasm.
Positive_regulation (Increased) of Positive_regulation (activation) of alpha-adrenoceptor associated with muscular spasm
1) Confidence 0.70 Published 2001 Journal Eur. Heart J. Section Abstract Doc Link 11913483 Disease Relevance 0.20 Pain Relevance 0.13
CONCLUSIONS: The results suggest that in the female rabbit in vivo activation of alpha1-adrenoceptors increased the urethral pressure.
Positive_regulation (increased) of Positive_regulation (activation) of alpha1
2) Confidence 0.67 Published 2000 Journal Scand. J. Urol. Nephrol. Section Body Doc Link 10961466 Disease Relevance 0.05 Pain Relevance 0
While the binding of certain basic drugs may increase after transplantation due to an increase in the concentration of alpha 1-acid glycoprotein, a lower albumin concentration may mask this effect.
Spec (may) Positive_regulation (increase) of Positive_regulation (increase) of alpha 1
3) Confidence 0.49 Published 1989 Journal Clin Pharmacokinet Section Abstract Doc Link 2656047 Disease Relevance 0.32 Pain Relevance 0.17
In particular, activation of alpha 2-adrenoceptors stimulates GH secretion via endogenous GHRH release, although a mechanism operating to inhibit hypothalamic SS release cannot be excluded; stimulation of alpha 1-adrenoceptors is inhibitory to GH secretion exclusively via an increased release of hypothalamic SS.
Positive_regulation (inhibitory) of Positive_regulation (stimulation) of alpha 1 associated with somatostatin
4) Confidence 0.49 Published 1987 Journal Endocrinology Section Abstract Doc Link 2881775 Disease Relevance 0 Pain Relevance 0.33
Contractions mediated via alpha 2-adrenoceptors do not appear to be more susceptible to diltiazem than those caused by activation of alpha 1-adrenoceptors and prostaglandin F2 alpha receptors.
Positive_regulation (caused) of Positive_regulation (activation) of alpha 1
5) Confidence 0.49 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2896597 Disease Relevance 0 Pain Relevance 0.13
The activation of alpha 1-adrenergic receptors leads to an increase in [Ca2+]i.
Positive_regulation (increase) of Positive_regulation (activation) of alpha 1
6) Confidence 0.49 Published 1985 Journal Mol. Pharmacol. Section Abstract Doc Link 2991734 Disease Relevance 0 Pain Relevance 0.20
Antagonism of the 2-AT derivative, DR-31, and clonidine by yohimbine in both tests argues for the involvement of alpha 2-adrenoreceptors in the mediation of these behavioral effects. alpha 1-Adrenoreceptors may also mediate an inhibition of exploratory activity since the inhibition induced by methoxamine was antagonized by phenoxybenzamine (POB) but not by yohimbine.
Positive_regulation (involvement) of Positive_regulation (mediation) of alpha 1 associated with clonidine
7) Confidence 0.49 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6249622 Disease Relevance 0.09 Pain Relevance 0.52
BACKGROUND AND OBJECTIVE: Inflammation promotes hyperalgesia and increases opioid binding protein (alpha1-acid glycoprotein) inducing increased opioid requirement.
Positive_regulation (increases) of Positive_regulation (inducing) of alpha1 associated with hyperalgesia, inflammation and opioid
8) Confidence 0.49 Published 2003 Journal Eur J Anaesthesiol Section Abstract Doc Link 14690097 Disease Relevance 0.70 Pain Relevance 0.65
CONCLUSIONS: Postoperative increases in plasma alpha1-acid glycoprotein concentrations enhance the protein binding of ropivacaine and pipecoloxylidide, causing divergence of total and unbound plasma concentrations.


Positive_regulation (enhance) of Positive_regulation (increases) of alpha1 in plasma
9) Confidence 0.49 Published 2000 Journal Anesthesiology Section Body Doc Link 10910488 Disease Relevance 0 Pain Relevance 0
The glial norepinephrine response was blocked by phentolamine but not by the removal of external Ca2+, indicating a direct activation of alpha1-adrenergic receptors that mediated release of Ca2+ from intracellular stores.
Positive_regulation (mediated) of Positive_regulation (activation) of alpha1-adrenergic in external
10) Confidence 0.07 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9166734 Disease Relevance 0 Pain Relevance 0.29
Noradrenaline produced a similar increase in GABA(A)-IPSCs during acute opioid withdrawal, but this increase resulted from activation of beta-adrenergic receptors, adenylyl cyclase, and protein kinase A, as well as alpha1-adrenergic receptors.
Positive_regulation (increase) of Positive_regulation (activation) of alpha1-adrenergic associated with gaba, noradrenaline, withdrawal and opioid
11) Confidence 0.02 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15385602 Disease Relevance 0.17 Pain Relevance 1.15

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