INT276946

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.01
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hspd1, Tlr2) mitochondrion (Hspd1) Golgi apparatus (Hspd1)
intracellular (Tlr2) cytosol (Hspd1) protein folding (Hspd1)
Hspd1 (Mus musculus)
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 23 97.36 Very High Very High Very High
Inflammation 71 97.00 Very High Very High Very High
tolerance 9 83.40 Quite High
rheumatoid arthritis 7 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 84 98.40 Very High Very High Very High
INFLAMMATION 73 97.00 Very High Very High Very High
Infection 6 88.72 High High
Yersinia Infection 1 81.92 Quite High
Metastasis 48 71.80 Quite High
Brain Tumor 1 64.96 Quite High
Viral Infection 1 61.64 Quite High
Necrosis 3 58.96 Quite High
Lewis Lung Carcinoma 2 55.28 Quite High
Skin Cancer 8 29.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consensually, recombinant human HSP60 activates TLR2 and Stat3 and subsequently up-regulates the expression of SOCS3 [27].
HSP60 Positive_regulation (activates) of TLR2
1) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.65 Pain Relevance 0.04
Further studies showed that HSP60 and Gp96 can tightly bind to LPS in a saturable manner and enhance its biological activity, as well as that of the TLR2 ligand Pam3Cys [43–45].
HSP60 Positive_regulation (enhance) of TLR2
2) Confidence 0.14 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.37 Pain Relevance 0.13

General Comments

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