INT276950

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Context Info
Confidence 0.22
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.25
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hspd1, Tlr2) mitochondrion (Hspd1) Golgi apparatus (Hspd1)
intracellular (Tlr2) cytosol (Hspd1) protein folding (Hspd1)
Hspd1 (Mus musculus)
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 9 95.04 Very High Very High Very High
chemokine 5 94.48 High High
tolerance 9 79.96 Quite High
Inflammation 4 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 81 100.00 Very High Very High Very High
Shock 2 100.00 Very High Very High Very High
Experimental Melanoma 5 89.56 High High
Metastasis 46 87.32 High High
Skin Cancer 8 5.00 Very Low Very Low Very Low
Death 7 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Immunotherapy Of Cancer 2 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Pulmonary Fibrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, heat shock protein 60 released by tumor cells caused a persistent activation of TLR2 and was critical in the constitutive activation of transcription factor Stat3, leading to the release of immunosuppressive cytokines and chemokines.
heat shock protein 60 Positive_regulation (caused) of Positive_regulation (activation) of TLR2 associated with chemokine, cancer, shock and cytokine
1) Confidence 0.22 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2716531 Disease Relevance 1.25 Pain Relevance 0.13

General Comments

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