INT276953

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Context Info
Confidence 0.38
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.93
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr2, Stat3) plasma membrane (Tlr2, Stat3) cytoplasm (Tlr2, Stat3)
cell proliferation (Stat3) nucleus (Stat3) intracellular (Tlr2)
Tlr2 (Mus musculus)
Stat3 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 10 94.36 High High
cytokine 18 93.88 High High
tolerance 18 88.20 High High
agonist 4 82.72 Quite High
Inflammation 8 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 162 99.84 Very High Very High Very High
Metastasis 92 76.60 Quite High
Yersinia Infection 2 76.40 Quite High
Brain Tumor 2 69.76 Quite High
Lewis Lung Carcinoma 2 60.08 Quite High
Skin Cancer 16 34.12 Quite Low
Immunotherapy Of Cancer 4 16.24 Low Low
Death 14 5.00 Very Low Very Low Very Low
Experimental Melanoma 10 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secondly, HSP60 activation of TLR2 mediates the expression and phosphorylation of Stat3 in tumor cells.
Positive_regulation (activation) of TLR2 Positive_regulation (mediates) of Phosphorylation (phosphorylation) of Stat3 associated with cancer
1) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.73 Pain Relevance 0.04
As illustrated in the Fig. 2, activation of TLR2 resulted in a significant increase in the expression and phosphorylation of Stat3 in concentration- and time- dependent manner (Fig. 2A–D).
Positive_regulation (activation) of TLR2 Positive_regulation (increase) of Phosphorylation (phosphorylation) of Stat3
2) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.20 Pain Relevance 0.22

General Comments

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