INT276968

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Context Info
Confidence 0.20
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.54
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (Stat3) cytoplasm (Stat3) signal transducer activity (Stat3)
cell proliferation (Stat3) extracellular space (Il6) signal transduction (Stat3)
Anatomy Link Frequency
hepatocyte 2
nucleus 2
Il6 (Mus musculus)
Stat3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 37 96.96 Very High Very High Very High
cytokine 22 87.24 High High
rheumatoid arthritis 1 50.00 Quite Low
chemokine 6 46.48 Quite Low
agonist 2 34.84 Quite Low
Arthritis 5 29.20 Quite Low
tolerance 9 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
abatacept 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 3 99.12 Very High Very High Very High
INFLAMMATION 38 96.96 Very High Very High Very High
Rheumatoid Arthritis 61 96.00 Very High Very High Very High
Cancer 81 86.24 High High
Disease 15 83.76 Quite High
Injury 1 82.96 Quite High
Anaemia 9 67.84 Quite High
Osteoporosis 9 61.52 Quite High
Metastasis 46 50.00 Quite Low
Hypercalcemia 6 45.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-6 is a principal stimulator of acute-phase protein synthesis through hepatocyte stimulation.
IL-6 Positive_regulation (stimulator) of Gene_expression (synthesis) of acute-phase protein in hepatocyte
1) Confidence 0.20 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 1.38 Pain Relevance 0.21
Similar to the IL-6- plus IL-10- neutralizing Ab, the TLR2 shRNA markedly inhibited the expression, phosphorylation and nucleus translocation of Stat3, which were partially restored by rmIL-6 and rmIL-10 (Fig. 2D–F).
rmIL-6 Positive_regulation (restored) of Gene_expression (expression) of Stat3 in nucleus
2) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.16 Pain Relevance 0

General Comments

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