INT27703

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Context Info
Confidence 0.52
First Reported 1989
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.08
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Pol1 (Mus musculus)
Pain Link Frequency Relevance Heat
neuralgia 1 83.68 Quite High
Pain 1 62.96 Quite High
Post herpetic neuralgia 3 60.16 Quite High
Disease Link Frequency Relevance Heat
Herpes Zoster 20 99.14 Very High Very High Very High
Infection 1 90.80 High High
Neuralgia 4 83.68 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 80.96 Quite High
Cancer 1 71.32 Quite High
Syndrome 1 70.20 Quite High
Pain 1 62.96 Quite High
Herpes Simplex Virus Infection 1 59.76 Quite High
Vomiting 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the antiviral drugs available at present, aciclovir has proved especially useful, acting as an inhibitor of viral DNA polymerase.
Negative_regulation (inhibitor) of viral DNA polymerase
1) Confidence 0.52 Published 1989 Journal Z. Hautkr. Section Abstract Doc Link 2660444 Disease Relevance 1.30 Pain Relevance 0.08
It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage.
Negative_regulation (inhibition) of viral DNA polymerase associated with herpes zoster
2) Confidence 0.52 Published 2004 Journal Drugs Section Abstract Doc Link 15341504 Disease Relevance 0.78 Pain Relevance 0.18

General Comments

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