INT277039

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 4.05
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Nppb) extracellular region (Nppb) nucleus (Nppb)
cytoplasm (Nppb)
Anatomy Link Frequency
face 4
Nppb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 3 9.68 Low Low
cva 15 5.00 Very Low Very Low Very Low
ischemia 12 5.00 Very Low Very Low Very Low
Angina 6 5.00 Very Low Very Low Very Low
beta blocker 3 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 54 100.00 Very High Very High Very High
Stress 9 98.00 Very High Very High Very High
Myocardial Infarction 174 90.36 High High
Hypertension 6 89.00 High High
Natriuresis 72 86.08 High High
Chronic Renal Failure 6 52.96 Quite High
Heart Disease 3 48.00 Quite Low
Pressure And Volume Under Development 3 35.52 Quite Low
Renal Disease 27 33.04 Quite Low
Dyspnea 42 32.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, recent data from the ICON study group have shown that despite a decreased production of NT-proBNP in obese subjects, NT-proBNP keeps its diagnostic capabilities across all BMI categories.
Negative_regulation (decreased) of Gene_expression (production) of NT-proBNP associated with obesity
1) Confidence 0.59 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.17 Pain Relevance 0
Following weight-loss surgery, postoperative BMI decreased dramatically in the study subjects, with parallel rise in both NT-proBNP and BNP over time.86 Importantly, BNP and NT-proBNP production in obese subjects is suppressed in the face of higher levels of ventricular wall stress than in non-obese patients.
Negative_regulation (suppressed) of Gene_expression (production) of NT-proBNP in face associated with stress and obesity
2) Confidence 0.51 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.44 Pain Relevance 0
Following weight-loss surgery, postoperative BMI decreased dramatically in the study subjects, with parallel rise in both NT-proBNP and BNP over time.86 Importantly, BNP and NT-proBNP production in obese subjects is suppressed in the face of higher levels of ventricular wall stress than in non-obese patients.
Negative_regulation (suppressed) of Gene_expression (production) of BNP in face associated with stress and obesity
3) Confidence 0.37 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.44 Pain Relevance 0

General Comments

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