INT277061

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.56
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL11A1) cell adhesion (COL11A1) protein binding, bridging (COL11A1)
extracellular matrix organization (COL11A1)
COL11A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 84 99.84 Very High Very High Very High
Inflammation 23 50.00 Quite Low
Arthritis 16 50.00 Quite Low
chemokine 1 10.64 Low Low
Chronic pancreatitis 9 5.00 Very Low Very Low Very Low
methotrexate 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Infliximab 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 85 99.84 Very High Very High Very High
Primary Sclerosing Cholangitis 31 99.84 Very High Very High Very High
Cirrhosis 46 99.20 Very High Very High Very High
Rheumatoid Arthritis 21 84.72 Quite High
Disease 36 68.56 Quite High
Arthropathy 2 53.76 Quite High
Injury 6 53.60 Quite High
Cancer 47 50.00 Quite Low
INFLAMMATION 22 50.00 Quite Low
Arthritis 19 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this group, collagen type XI alpha 1 (Col11a1) was the most specific gene with a 13.74-fold upregulation in PSC compared to HSC.
Positive_regulation (upregulation) of Col11a1 associated with cirrhosis and primary sclerosing cholangitis
1) Confidence 0.43 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 0.66 Pain Relevance 0
Coll 2-1 is significantly elevated in OA patients compared to control (267.45 ± 26.42 nmol/l versus 126.78 ± 6.61 nmol/l) (Henrotin et al. 2004).
Positive_regulation (elevated) of Coll 2-1 associated with osteoarthritis
2) Confidence 0.03 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716783 Disease Relevance 0.90 Pain Relevance 0.28

General Comments

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