INT27710

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Context Info
Confidence 0.36
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.54
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (B2m)
Anatomy Link Frequency
synovium 1
B2m (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 42 99.54 Very High Very High Very High
shoulder pain 2 96.88 Very High Very High Very High
carpal tunnel syndrome 2 95.68 Very High Very High Very High
spinal inflammation 1 83.52 Quite High
cytokine 7 27.20 Quite Low
chemokine 13 26.48 Quite Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
diabetic neuropathy 2 5.00 Very Low Very Low Very Low
halothane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 7 99.98 Very High Very High Very High
Arthropathy 4 99.98 Very High Very High Very High
INFLAMMATION 47 99.54 Very High Very High Very High
Renal Failure 6 98.66 Very High Very High Very High
Apoptosis 5 98.66 Very High Very High Very High
Bone Cysts 2 98.08 Very High Very High Very High
Shoulder Pain 2 96.88 Very High Very High Very High
Aging 64 96.76 Very High Very High Very High
Carpal Tunnel Syndrome 2 95.68 Very High Very High Very High
Rheumatic Diseases 2 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that peritoneal dialysis, like hemodialysis, may lead to the development of an arthropathy associated with beta 2m accumulation and beta 2m amyloid deposition.
beta 2m Binding (associated) of associated with renal failure, alzheimer's dementia and arthropathy
1) Confidence 0.36 Published 1989 Journal Arthritis Rheum. Section Abstract Doc Link 2660798 Disease Relevance 1.21 Pain Relevance 0.17
Amyloid reacting with anti-beta 2m was demonstrated in the hip synovium of 1 patient.
beta 2m Binding (reacting) of in synovium associated with alzheimer's dementia
2) Confidence 0.32 Published 1989 Journal Arthritis Rheum. Section Abstract Doc Link 2660798 Disease Relevance 1.08 Pain Relevance 0.19
OBJECTIVE: A fully complexed HLA-B27 molecule consists of a heavy chain, a peptide, and beta2-microglobulin (beta2m).
beta2m Binding (complexed) of
3) Confidence 0.31 Published 2002 Journal J. Rheumatol. Section Abstract Doc Link 12022359 Disease Relevance 0.24 Pain Relevance 0.12
B2m is a serum protein found in association with the MHC class I heavy chain on the surface of nearly all nucleated cells.
B2m Binding (association) of
4) Confidence 0.30 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.37 Pain Relevance 0
B pathway, such as STAT1 and TLR1; cell proliferation/apoptosis, such as IER3; EHF; LRPAP1 and inflammation such as CCL7; CXCL16; B2M; IL7R and LGALS3 were among the genes whose transcripts were increased in the context of both in vivo aging and in vitro senescence.
B2M Binding (were) of associated with aging, inflammation and apoptosis
5) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.64 Pain Relevance 0.05

General Comments

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