INT277117

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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.22
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (POMZP3) cellular_component (POMZP3) biological_process (POMZP3)
POMZP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 11 99.92 Very High Very High Very High
Potency 2 77.76 Quite High
headache 4 36.16 Quite Low
agonist 4 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
drug abuse 1 5.00 Very Low Very Low Very Low
dopamine receptor 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 26 84.40 Quite High
Pressure Volume 2 Under Development 3 80.68 Quite High
Akathisia 2 55.92 Quite High
Schizophrenia 21 50.00 Quite Low
Psychosis 7 50.00 Quite Low
Headache 4 36.16 Quite Low
Hallucination 3 35.36 Quite Low
Sleep Disorders 4 33.12 Quite Low
Hypotension 3 26.28 Quite Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 18.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, single dosing in healthy volunteers is sufficient for an early go/no-go decision for the Angiotensin-II receptor antagonist by providing PoM by use of a laboratory biomarker and allows establishing a dose-effect relationship predictive for short-term effects in patients.
Positive_regulation (providing) of PoM associated with antagonist
1) Confidence 0.09 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717814 Disease Relevance 0.17 Pain Relevance 0.09
Both patient and caregiver POM ratings for aripiprazole increased during the 12-week switching phase.
Positive_regulation (increased) of POM
2) Confidence 0.04 Published 2010 Journal Ann Gen Psychiatry Section Body Doc Link PMC2949853 Disease Relevance 0.06 Pain Relevance 0

General Comments

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