INT277136

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.45
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ebp) chromosome (Mlh1) endoplasmic reticulum (Ebp)
ATPase activity (Mlh1) nucleus (Mlh1) cell cycle (Mlh1)
Anatomy Link Frequency
MLH1 2
Ebp (Mus musculus)
Mlh1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microsatellite Instability 6 100.00 Very High Very High Very High
Cancer 116 99.32 Very High Very High Very High
Colon Cancer 8 97.08 Very High Very High Very High
Pancreatic Cancer 3 38.48 Quite Low
Breast Cancer 3 34.92 Quite Low
Ovarian Diseases 1 32.92 Quite Low
Ovarian Cancer 1 23.24 Low Low
Lung Cancer 3 16.20 Low Low
Skin Cancer 1 11.40 Low Low
Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies of methylation in colon cancer revealed increased frequencies of promoter methylation in the mismatch repair gene MLH1 in MSI-positive tumours suggesting that hypermethylation leads to MSI through silencing of MLH1.
MSI Positive_regulation (leads) of Gene_expression (silencing) of MLH1 in MLH1 associated with cancer, colon cancer and microsatellite instability
1) Confidence 0.01 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717819 Disease Relevance 1.45 Pain Relevance 0

General Comments

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