INT277162

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.10
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pdgfrb) plasma membrane (Pdgfrb) nucleus (Pdgfrb)
kinase activity (Pdgfrb) lysosome (Pdgfrb) cytoplasm (Pdgfrb)
Pdgfrb (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 28 72.92 Quite High
chemokine 8 5.00 Very Low Very Low Very Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 136 94.48 High High
Disease 28 78.80 Quite High
Metastasis 22 71.96 Quite High
Skin Cancer 1 68.44 Quite High
Cancer 85 65.24 Quite High
Recurrence 4 57.28 Quite High
Malignant Neoplastic Disease 15 50.00 Quite Low
Dermatofibrosarcoma 3 50.00 Quite Low
Ring Chromosomes 10 22.88 Low Low
Generaliased Trisomy 2 13.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This functional PDGF-B-like protein form homodimers and, by an autocrine and paracrine loops, promote ligand driving proliferation through the two receptors PDGFR?
Positive_regulation (promote) of PDGFR Binding (receptors) of
1) Confidence 0.06 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721290 Disease Relevance 0.40 Pain Relevance 0
A similar autocrine loop may exist for PDGF and its receptor PDGFR (Ascoli, 1995; Langerak, 1996; Klominek, 1998a).
Spec (may) Positive_regulation (exist) of PDGFR Binding (receptor) of
2) Confidence 0.05 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 0.70 Pain Relevance 0.07

General Comments

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