INT277192

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.86 Pain Relevance 1.04

cytosol (SUGT1, SLC6A4) endosome (SLC6A4) mitosis (SUGT1) plasma membrane (SLC6A4)

SUGT1 (Homo sapiens) SLC6A4 (Homo sapiens)

Pain Link Frequency Relevance Heat Serotonin 16 81.84 drug abuse 3 80.00 Lasting pain 9 77.44 Pain 48 75.92 Opioid 18 75.20 Fibrositis 2 74.96 spastic colon 1 73.44 headache 2 69.68 Spinal cord 4 68.20 Antinociceptive 5 66.68

Disease Link Frequency Relevance Heat Neurosis 1 88.40 Anxiety Disorder 6 81.92 Drug Dependence 3 80.00 Pain 58 77.44 Syndrome 1 76.40 Sleep Disorders 2 74.96 Functional Bowel Disorder 1 73.44 Tension-type Headache 1 70.72 Targeted Disruption 4 5.00 Nociception 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The s-allele reduces the transcriptional efficiency of the 5-HTT gene promoter, resulting in decreased 5-HTT expression and availability [9].

allele Positive_regulation (resulting) of Gene_expression (expression) of 5-HTT

1) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2717925 Disease Relevance 0.86 Pain Relevance 1.04

General Comments

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