INT27723

Context Info Confidence 0.45 First Reported 1981 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 1.14 Pain Relevance 0.44

peptidase activity (Ren) extracellular space (Ren) extracellular region (Ren) intracellular (Ren) response to stress (Ren)

Anatomy Link Frequency plasma 2 blood 2 Ren (Rattus norvegicus)

Pain Link Frequency Relevance Heat Clonidine 6 100.00 antagonist 2 100.00 anesthesia 3 60.80 Neuronal nitric oxide synthase 1 39.44

Disease Link Frequency Relevance Heat Hypotension 3 99.84 Natriuresis 5 99.68 Pressure Volume 2 Under Development 6 94.08 Cv Unclassified Under Development 1 86.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The effects of renin inhibition were also tested under conditions where the renin-angiotensin system was stimulated.

Regulation (effects) of Negative_regulation (inhibition) of renin

1) Confidence 0.45 Published 1989 Journal Hypertension Section Abstract Doc Link 2661429 Disease Relevance 0.32 Pain Relevance 0

An additive effect of combined converting enzyme and renin inhibition on blood pressure lowering and inhibition of plasma angiotensin II was found in rats anesthetized with Inactin.

Regulation (effect) of Negative_regulation (inhibition) of renin in blood associated with hypotension

2) Confidence 0.45 Published 1989 Journal Hypertension Section Abstract Doc Link 2661429 Disease Relevance 0.32 Pain Relevance 0

However, neither renal denervation nor nNOS inhibition affects either the renin down-regulation or the natriuretic response to acute sodium loading.

Regulation (affects) of Negative_regulation (down-regulation) of renin associated with natriuresis

3) Confidence 0.26 Published 2008 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 18234741 Disease Relevance 0.32 Pain Relevance 0.06

Dogs anaesthetised with pentobarbital were used to study the effects of the alpha-adrenoceptor antagonists phentolamine and piperoxan on the clonidine-induced suppression of plasma renin activity (PRA).

Regulation (effects) of Negative_regulation (suppression) of renin in plasma associated with antagonist and clonidine

4) Confidence 0.15 Published 1981 Journal Clin Exp Hypertens Section Abstract Doc Link 6120802 Disease Relevance 0.17 Pain Relevance 0.38

General Comments

This test has worked.