INT277232

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 6.76
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (aicda) cellular_component (aicda) biological_process (aicda)
cytoplasm (aicda)
Anatomy Link Frequency
neurons 4
hippocampus 2
aicda (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 130 98.96 Very High Very High Very High
imagery 60 86.76 High High
withdrawal 110 72.32 Quite High
nMDA receptor 130 70.40 Quite High
Action potential 280 65.08 Quite High
Glutamate receptor 10 35.36 Quite Low
antagonist 32 24.64 Low Low
addiction 12 5.00 Very Low Very Low Very Low
ketamine 10 5.00 Very Low Very Low Very Low
tetrodotoxin 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 830 100.00 Very High Very High Very High
Aging 50 98.84 Very High Very High Very High
Disease 56 98.64 Very High Very High Very High
Neurodegenerative Disease 40 96.20 Very High Very High Very High
Convulsion 60 94.04 High High
Cognitive Disorder 10 90.84 High High
Infection 40 88.32 High High
Stress 40 87.44 High High
Parkinson's Disease 10 84.56 Quite High
Apoptosis 240 75.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study we show that expression of AID genes renders the mitochondria of hippocampal neurons more resistant to harmful conditions.
Gene_expression (expression) of AID in neurons associated with death
1) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2718706 Disease Relevance 0.93 Pain Relevance 0.04
However, high-level, constitutive expression of individual AID genes may be sufficient to activate or inactivate down-stream regulators of survival.
Gene_expression (expression) of AID associated with death
2) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2718706 Disease Relevance 0.76 Pain Relevance 0
Stereotaxic injection was used to deliver rAAVs carrying expression cassettes for AID genes or appropriate negative controls (i.e. rAAV-LacZ and rAAV-Empty) to the dorsal hippocampus of male Sprague-Dawley rats weighing 230 to 250 g.
Gene_expression (expression) of AID in hippocampus associated with hippocampus and death
3) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2718706 Disease Relevance 0.72 Pain Relevance 0.08
Although they may act in concert to collectively provide full neuroprotection, over-expression of individual AID genes is sufficient to promote survival.
Gene_expression (over) of AID associated with death
4) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2718706 Disease Relevance 0.51 Pain Relevance 0
[61]–[64], or the secreted AID genes Serpinb2 and Inhibin ?
Gene_expression (genes) of AID associated with death
5) Confidence 0.43 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2718706 Disease Relevance 0.65 Pain Relevance 0
We first carried out gain-of-function experiments in which we used rAAV-mediated gene delivery to over-express Flag-tagged AID proteins in cultured hippocampal neurons.
Gene_expression (express) of AID in neurons associated with death
6) Confidence 0.38 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2718706 Disease Relevance 0.92 Pain Relevance 0.07
Although they may act in concert to collectively provide full neuroprotection, over-expression of individual AID genes is sufficient to promote survival.
Gene_expression (expression) of AID associated with death
7) Confidence 0.38 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2718706 Disease Relevance 0.51 Pain Relevance 0
Both in disease and aging, health and functionality of neurons may be preserved by expressing AID genes or by restoring or enhancing key signals, in particular nuclear calcium.


Gene_expression (expressing) of AID in neurons associated with aging, disease and death
8) Confidence 0.38 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2718706 Disease Relevance 0.71 Pain Relevance 0.04
In contrast, expression of AID genes in the CA1 area of the injected side of the hippocampus protected against KA-induced cell death (Figure 7).
Gene_expression (expression) of AID in hippocampus associated with hippocampus and death
9) Confidence 0.38 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2718706 Disease Relevance 0.59 Pain Relevance 0.21
In contrast, in hippocampal neurons that had been infected with rAAV to express the AID genes Npas4, Inhibin ?
Gene_expression (express) of AID in neurons associated with death
10) Confidence 0.38 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2718706 Disease Relevance 0.48 Pain Relevance 0.11
In contrast, a more recent study models the residues upstream of the AID region (the IS6-AID linker) as an invariably rigid helical segment (Vitko et al., 2008) that positions the ?
Gene_expression (region) of AID
11) Confidence 0.04 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0 Pain Relevance 0
In contrast, a more recent study models the residues upstream of the AID region (the IS6-AID linker) as an invariably rigid helical segment (Vitko et al., 2008) that positions the ?
Gene_expression (linker) of AID
12) Confidence 0.04 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0 Pain Relevance 0

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