INT277234

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Context Info
Confidence 0.39
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.88
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (aicda) cellular_component (aicda) biological_process (aicda)
cytoplasm (aicda)
Anatomy Link Frequency
neuronal 1
aicda (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 168 99.64 Very High Very High Very High
Hippocampus 78 23.96 Low Low
nMDA receptor 78 5.00 Very Low Very Low Very Low
withdrawal 66 5.00 Very Low Very Low Very Low
imagery 36 5.00 Very Low Very Low Very Low
antagonist 18 5.00 Very Low Very Low Very Low
tetrodotoxin 6 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
Pyramidal cell 6 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 498 100.00 Very High Very High Very High
Neuroblastoma 6 80.08 Quite High
Apoptosis 144 66.68 Quite High
Stress 24 38.56 Quite Low
Convulsion 36 5.00 Very Low Very Low Very Low
Aging 30 5.00 Very Low Very Low Very Low
Disease 30 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 24 5.00 Very Low Very Low Very Low
Infection 24 5.00 Very Low Very Low Very Low
Repression 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We next investigated the role of the nuclear calcium/calmodulin-dependent protein kinase IV (CaMKIV) in the regulation of AID genes.
Spec (investigated) Regulation (regulation) of AID associated with death
1) Confidence 0.39 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2718706 Disease Relevance 0.41 Pain Relevance 0.03
In addition to CREB, other CBP-recruiting transcription factors may contribute to the regulation of AID genes by nuclear calcium signaling.
Regulation (regulation) of AID associated with death
2) Confidence 0.39 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2718706 Disease Relevance 0.36 Pain Relevance 0
Given that 7 out of 9 AID genes are putative regulators of gene expression, the existence of common target genes that are part of a ‘second wave’ transcriptional response is conceivable.
Regulation (regulators) of AID associated with death
3) Confidence 0.29 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2718706 Disease Relevance 0.70 Pain Relevance 0
Using QRT-PCR, we confirmed the regulation of each AID gene by AP bursting and nuclear calcium signaling; the regulation of Btg2 by nuclear calcium signaling has been established previously [6].
Regulation (regulation) of AID associated with action potential and death
4) Confidence 0.17 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2718706 Disease Relevance 0.76 Pain Relevance 0.09
Information retrieved from two databases (the CREB ‘regulon’ (http://saco.ohsu.edu/) [39] and the CREB target gene database (http://natural.salk.edu/creb/) [40] indicated that a large fraction of the nuclear calcium regulated gene pool (56%) and all AID genes except Npas4 contain one or several CREs or CRE-like sequences, suggesting that they could be CREB target genes (Table S1).
Regulation (regulated) of AID associated with death
5) Confidence 0.17 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2718706 Disease Relevance 0.34 Pain Relevance 0
Indeed, 56% of nuclear calcium-regulated genes and all AID genes except Npas4 are known or putative CREB targets (Table S1), underscoring the importance of the nuclear calcium-CREB axis in neuronal survival.


Regulation (targets) of AID in neuronal associated with death
6) Confidence 0.17 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2718706 Disease Relevance 0.31 Pain Relevance 0

General Comments

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