INT277254

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.26
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Satb2) DNA binding (Satb2) cytoplasm (Satb2)
Anatomy Link Frequency
jaw 1
Satb2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 4 75.72 Quite High
tolerance 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autism 8 99.80 Very High Very High Very High
Death 4 98.72 Very High Very High Very High
Syndrome 64 92.44 High High
Pica 4 89.08 High High
Tooth Abnormalities 16 89.00 High High
Aggression 20 88.68 High High
Intellectual Impairment 52 87.72 High High
Language Development Disorders 12 83.88 Quite High
Learning Disorders 12 83.16 Quite High
Osteoporosis 8 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, one individual with a balanced translocation disrupting SATB2 had autism spectrum disorder [9].
Negative_regulation (disrupting) of SATB2 associated with autism
1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719055 Disease Relevance 0.58 Pain Relevance 0.04
A fourth case of a balanced translocation predicted to disrupt the SATB2 gene has been reported in an individual with autism spectrum disorder and developmental dyspraxia [9].
Negative_regulation (disrupt) of SATB2 associated with autism
2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719055 Disease Relevance 0.99 Pain Relevance 0
Loss of Satb2 correlates with increased cell death in the developing jaw along with altered expression of other craniofacial developmental genes [10].
Negative_regulation (Loss) of Satb2 in jaw associated with death
3) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719055 Disease Relevance 0.84 Pain Relevance 0
In addition, mouse models have demonstrated haploinsufficiency of Satb2 results in craniofacial defects that phenocopy those caused by 2q32q33 deletion in humans; moreover, full functional loss of Satb2 amplifies these defects.
Negative_regulation (loss) of Satb2
4) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719055 Disease Relevance 0.85 Pain Relevance 0

General Comments

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