INT277269

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Context Info
Confidence 0.40
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.89
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (Celf1) mRNA processing (Celf1) RNA binding (Celf1)
nucleus (Celf1) cytoplasm (Celf1)
Anatomy Link Frequency
myotubes 2
Celf1 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 10 96.12 Very High Very High Very High
imagery 10 94.28 High High
gABA 9 91.32 High High
cytokine 6 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
spastic colon 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
interneuron 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 77 99.24 Very High Very High Very High
Stress 3 91.96 High High
Myotonic Dystrophy 66 89.44 High High
Toxicity 48 74.88 Quite High
Disease 50 50.00 Quite Low
Spinocerebellar Ataxia Type 2 5 50.00 Quite Low
Congenital Anomalies 33 41.76 Quite Low
Frailty 42 22.00 Low Low
Myotonia 42 5.00 Very Low Very Low Very Low
Cataract 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to DM1 myotubes, CUGBP1-eIF2 complexes are increased in DM2 differentiating myotubes similar to normal myotubes (Timchenko, L.; unpublished; Fig. 6).
Positive_regulation (increased) of CUGBP1 Binding (complexes) of in myotubes
1) Confidence 0.40 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.51 Pain Relevance 0
The formation of these complexes depends on CUG/CCUG RNAs because ectopic expression of pure CUG or CCUG RNAs causes interaction of CUGBP1 with un-aggregated CUG and CCUG repeats [39,52].
Positive_regulation (causes) of CUGBP1 Binding (interaction) of
2) Confidence 0.37 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.14 Pain Relevance 0
It would be interesting to determine if CUG repeats elevate CUGBP1 RNA-binding activity in these transgenic mice.
Positive_regulation (elevate) of CUGBP1 Binding (binding) of associated with targeted disruption
3) Confidence 0.37 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.24 Pain Relevance 0
Further analysis of the Gabt4 CLIP tag showed that the putative Cugbp1 binding site maps to exon 7 (and overlaps the exon 7 5?
Positive_regulation (putative) of Cugbp1 Binding (binding) of
4) Confidence 0.23 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0 Pain Relevance 0.24

General Comments

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