INT277270

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.42
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Mbnl1) RNA binding (Mbnl1) nucleus (Mbnl1)
cytoplasm (Mbnl1)
Anatomy Link Frequency
brain 2
Mbnl1 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 20 96.36 Very High Very High Very High
imagery 20 92.20 High High
gABA 18 90.04 High High
interneuron 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 42 98.50 Very High Very High Very High
Spinocerebellar Ataxia Type 2 10 75.00 Quite High
Neurological Disease 2 56.04 Quite High
Huntington's Chorea 4 44.72 Quite Low
Targeted Disruption 40 36.00 Quite Low
Disease 22 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 8 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Hypopituitarism 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data demonstrate that CUGexp transcripts dysregulate MBNL/CELF regulated pathways in the brain and provide mechanistic insight into the CNS effects of other CUGexp disorders.
Regulation (dysregulate) of Regulation (regulated) of MBNL in brain
1) Confidence 0.45 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2719092 Disease Relevance 0.26 Pain Relevance 0.14
Because CUG-BP1 and MBNL1 have been shown to be antagonistic regulators of alternative splicing of a number of different targets from work done in the myotonic dystrophy field, we reasoned that CUG-BP1 CLIP tags would be also be good candidate targets for MBNL1 regulation.
Regulation (targets) of Regulation (regulation) of MBNL1 associated with frailty
2) Confidence 0.27 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.16 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox