INT27728

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Context Info
Confidence 0.04
First Reported 1989
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.59
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (LHB) small molecule metabolic process (LHB) extracellular region (LHB)
cellular nitrogen compound metabolic process (LHB) cell-cell signaling (LHB)
Anatomy Link Frequency
hypothalamus 2
LHB (Homo sapiens)
Pain Link Frequency Relevance Heat
Cluster headache 6 99.84 Very High Very High Very High
tolerance 6 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cluster Headache 6 99.84 Very High Very High Very High
Insulin Resistance 3 97.52 Very High Very High Very High
Congenital Anomalies 1 88.16 High High
Anovulation 1 84.80 Quite High
Polycystic Ovary Syndrome 48 83.76 Quite High
Reprotox - General 3 3 80.16 Quite High
Hirsutism 13 77.52 Quite High
Alopecia 8 75.60 Quite High
Hyperandrogenism 7 64.00 Quite High
Reprotox - General 1 8 57.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both the LH and the FSH profiles are thought secondary to a fundamental increase in GnRH from the hypothalamus which ultimately favors the gene expression of LHb over FSHb (Azziz et al 2006).
Negative_regulation (favors) of Gene_expression (expression) of LHb in hypothalamus
1) Confidence 0.04 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504056 Disease Relevance 1.14 Pain Relevance 0
Total, free and carrier protein-bound testosterone levels were significantly diminished only in chronic CH, where luteinizing hormone (LH) peak values after intravenous administration of LHRH were also decreased.
Negative_regulation (decreased) of Gene_expression (administration) of luteinizing hormone associated with cluster headache
2) Confidence 0.02 Published 1989 Journal Cephalalgia Section Abstract Doc Link 2663174 Disease Relevance 0.44 Pain Relevance 0.53

General Comments

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