INT277283

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.68
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc6a11) cytoplasm (Slc6a11)
Anatomy Link Frequency
synapse 4
Slc6a11 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 60 98.16 Very High Very High Very High
gABA 54 97.82 Very High Very High Very High
imagery 60 76.48 Quite High
interneuron 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
medulla 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 120 82.00 Quite High
Urological Neuroanatomy 6 81.88 Quite High
Frailty 126 80.72 Quite High
Sprains And Strains 12 55.68 Quite High
Spinocerebellar Ataxia Type 2 30 50.00 Quite Low
Neuroblastoma 6 43.44 Quite Low
Peripheral Arterial Disease 24 23.28 Low Low
Disease 66 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 12 5.00 Very Low Very Low Very Low
Huntington's Chorea 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Third, we demonstrate SCA8 CUGexp transcripts trigger increased expression of a CUGBP1-MBNL1 regulated CNS target, GABT4, in both mice and humans as well as in a human cell culture model and demonstrate the predicted loss of GABAergic inhibition within the granular cell layer occurs in these animals.
Positive_regulation (increased) of Gene_expression (expression) of GABT4 associated with gabaergic
1) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.08 Pain Relevance 0.05
Since Gabt4 was identified as a putative target of CUGBP1 by CLIP analysis and because increased Gabt4 expression could explain the increased cortical loss of GABAergic inhibition previously reported in our mice by reducing GABA at the synapse, we hypothesized that SCA8 CUGexp RNA dysregulates Cugbp1 and Mbnl1 pathways resulting in an increase in Gabt4 expression.
Positive_regulation (increased) of Gene_expression (expression) of Gabt4 in synapse associated with gaba and gabaergic
2) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.06 Pain Relevance 0.26
Because exon 7 of Gabt4 was identified as a potential Cugbp1 binding site, we investigated if increases in GABT4 expression could be related to misregulation of exon 7 alternative splicing.
Positive_regulation (increases) of Gene_expression (expression) of GABT4
3) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.13 Pain Relevance 0.03
Third, we demonstrate SCA8 CUGexp transcripts trigger increased expression of a CUGBP1-MBNL1 regulated CNS target, GABT4, in both mice and humans as well as in a human cell culture model and demonstrate the predicted loss of GABAergic inhibition within the granular cell layer occurs in these animals.
Positive_regulation (trigger) of Gene_expression (expression) of GABT4 associated with gabaergic
4) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.08 Pain Relevance 0.05
Since Gabt4 was identified as a putative target of CUGBP1 by CLIP analysis and because increased Gabt4 expression could explain the increased cortical loss of GABAergic inhibition previously reported in our mice by reducing GABA at the synapse, we hypothesized that SCA8 CUGexp RNA dysregulates Cugbp1 and Mbnl1 pathways resulting in an increase in Gabt4 expression.
Positive_regulation (increase) of Gene_expression (expression) of Gabt4 in synapse associated with gaba and gabaergic
5) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.25 Pain Relevance 0.24
Similar to humans, Gabt4 is also up-regulated in the SCA8 BAC-Exp and Mbnl1?
Positive_regulation (up) of Gene_expression (is) of Gabt4
6) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.08 Pain Relevance 0

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