INT277310

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Context Info
Confidence 0.18
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.10
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Tnnt2, Mbnl1) mRNA processing (Mbnl1) RNA binding (Mbnl1)
nucleus (Mbnl1) protein binding, bridging (Tnnt2)
Anatomy Link Frequency
skeletal muscle 1
Tnnt2 (Mus musculus)
Mbnl1 (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 1 6.92 Low Low
GABAergic 10 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
gABA 9 5.00 Very Low Very Low Very Low
interneuron 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 21 100.00 Very High Very High Very High
Disease 11 96.64 Very High Very High Very High
Targeted Disruption 20 93.32 High High
Muscle Disease 2 73.04 Quite High
Cognitive Disorder 1 70.56 Quite High
Hypopituitarism 2 55.72 Quite High
Spinocerebellar Ataxia Type 2 5 50.00 Quite Low
Neuromuscular Disease 1 36.00 Quite Low
Neurodegenerative Disease 2 9.68 Low Low
Peripheral Arterial Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, MBNL1 has been shown to bind directly to intronic elements of genes misregulated in DM cardiac and skeletal muscle (cTNT and IR) and to promote alternative splicing patterns normally found in adult tissue [21].
cTNT Binding (bind) of MBNL1 in skeletal muscle associated with frailty
1) Confidence 0.18 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 1.10 Pain Relevance 0

General Comments

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