INT277312

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.36
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Upf1, Mbnl1) cytoplasm (Upf1, Mbnl1) mRNA processing (Mbnl1)
nucleus (Mbnl1) helicase activity (Upf1) cell cycle (Upf1)
Anatomy Link Frequency
nucleus 2
Upf1 (Mus musculus)
Mbnl1 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 10 29.00 Quite Low
imagery 10 5.00 Very Low Very Low Very Low
gABA 9 5.00 Very Low Very Low Very Low
interneuron 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 11 80.24 Quite High
Frailty 21 73.12 Quite High
Spinocerebellar Ataxia Type 2 5 50.00 Quite Low
Targeted Disruption 20 48.64 Quite Low
Movement Disorders 2 33.44 Quite Low
Peripheral Arterial Disease 4 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Huntington's Chorea 2 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Hypopituitarism 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further studies will need to be done to determine if MBNL1 is expressed in the nucleus of these cells or if changes in MBNL1 splice forms affect its ability to bind to the CUG expansion transcripts.
Regulation (affect) of transcripts Binding (bind) of MBNL1 in nucleus
1) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.36 Pain Relevance 0

General Comments

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