INT277316

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.47
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Upf1, Slc6a11) transport (Slc6a11) RNA binding (Upf1)
helicase activity (Upf1) cell cycle (Upf1) DNA binding (Upf1)
Anatomy Link Frequency
SK-N-SH 1
Upf1 (Mus musculus)
Slc6a11 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 20 95.84 Very High Very High Very High
gABA 18 92.40 High High
imagery 20 25.00 Low Low
interneuron 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 2 98.52 Very High Very High Very High
Spinocerebellar Ataxia Type 2 10 75.00 Quite High
Huntington's Chorea 4 61.96 Quite High
Frailty 42 60.88 Quite High
Neurological Disease 2 25.00 Low Low
Targeted Disruption 40 5.00 Very Low Very Low Very Low
Disease 22 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 8 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test directly if increases in GABT4 are induced by SCA8 CUGexp or CAGexp transcripts, we examined their effects in human neuroblastoma SK-N-SH cells.
transcripts Positive_regulation (increases) of GABT4 in SK-N-SH associated with neuroblastoma
1) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.15 Pain Relevance 0
Additionally, alternative splicing changes and GAT4 upregulation are induced by CUGexp but not CAGexp transcripts.
transcripts Positive_regulation (upregulation) of GAT4
2) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2719092 Disease Relevance 0.32 Pain Relevance 0.09

General Comments

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