INT277317

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Context Info
Confidence 0.19
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Celf1, Slc6a11) transport (Slc6a11) mRNA binding (Celf1)
mRNA processing (Celf1) RNA binding (Celf1) nucleus (Celf1)
Anatomy Link Frequency
synapse 1
Celf1 (Mus musculus)
Slc6a11 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 9 96.52 Very High Very High Very High
GABAergic 10 95.92 Very High Very High Very High
imagery 10 79.72 Quite High
interneuron 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 20 57.36 Quite High
Spinocerebellar Ataxia Type 2 5 50.00 Quite Low
Sprains And Strains 2 31.04 Quite Low
Frailty 21 7.44 Low Low
Disease 11 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 4 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Huntington's Chorea 2 5.00 Very Low Very Low Very Low
Hypopituitarism 2 5.00 Very Low Very Low Very Low
Movement Disorders 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since Gabt4 was identified as a putative target of CUGBP1 by CLIP analysis and because increased Gabt4 expression could explain the increased cortical loss of GABAergic inhibition previously reported in our mice by reducing GABA at the synapse, we hypothesized that SCA8 CUGexp RNA dysregulates Cugbp1 and Mbnl1 pathways resulting in an increase in Gabt4 expression.
CUGBP1 Binding (target) of Gabt4 in synapse associated with gaba and gabaergic
1) Confidence 0.19 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.06 Pain Relevance 0.26

General Comments

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