INT277373

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Context Info
Confidence 0.72
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.61
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOXO3) embryo development (FOXO3) DNA binding (FOXO3)
response to stress (FOXO3) cytoplasm (FOXO3) cytosol (FOXO3)
FOXO3 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 26 74.80 Quite High
Diabetes Mellitus 166 70.88 Quite High
Pressure And Volume Under Development 2 58.96 Quite High
Cancer 35 57.64 Quite High
Obesity 8 52.32 Quite High
Retinoblastoma 1 18.08 Low Low
Insulin Resistance 24 5.00 Very Low Very Low Very Low
Disease 18 5.00 Very Low Very Low Very Low
Apoptosis 11 5.00 Very Low Very Low Very Low
Frailty 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The generated genelist included several noteworthy genes like the insulin receptor (INSR), insulin receptor substrate 2 (IRS2), protein phosphatase 1 (PPP1CB), lipoprotein lipase (LPL), hexokinase 2 (HK2), phosphorylase kinase (PHKA1), forkhead box O3A (FOXO3A), histone deacetylase 7A (HDAC7A), and NADH dehydrogenase (NDUFS1) (Table 2).
Phosphorylation (phosphorylase kinase) of FOXO3A
1) Confidence 0.72 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0.18 Pain Relevance 0
The generated genelist included several noteworthy genes like the insulin receptor (INSR), insulin receptor substrate 2 (IRS2), protein phosphatase 1 (PPP1CB), lipoprotein lipase (LPL), hexokinase 2 (HK2), phosphorylase kinase (PHKA1), forkhead box O3A (FOXO3A), histone deacetylase 7A (HDAC7A), and NADH dehydrogenase (NDUFS1) (Table 2).
Phosphorylation (phosphorylase kinase) of O3A
2) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0.18 Pain Relevance 0
We observed a decrease in phosphorylation of PI3K, AKT and FOXO3a (Ser318) (Fig. 4A) protein along with decreased activity of Cdk2 (Fig. 3B) with the RNAi treatments.
Phosphorylation (phosphorylation) of FOXO3a
3) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.24 Pain Relevance 0

General Comments

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