INT277381

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Context Info
Confidence 0.52
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.84
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HK2) mitochondrion (HK2) small molecule metabolic process (HK2)
carbohydrate metabolic process (HK2) kinase activity (HK2) transmembrane transport (HK2)
HK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 166 99.40 Very High Very High Very High
Obesity 8 97.76 Very High Very High Very High
Insulin Resistance 24 38.40 Quite Low
Frailty 4 34.72 Quite Low
Aging 2 26.44 Quite Low
Appetite Loss 2 26.04 Quite Low
Disease 18 18.68 Low Low
Pressure And Volume Under Development 2 7.44 Low Low
Toxicity 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Generally, the majority of fold changes were found to be modest (between 1.2 and 1.4) with some exceptions like HK2, which was downregulated 2.75 times in the ‘D’ group compared to controls.


Negative_regulation (downregulated) of HK2
1) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0 Pain Relevance 0
This can explain the decrease in expression of HK2 in the type 2 diabetics since subjects were submitted to a hyperinsulinemic clamp before samples were taken.
Negative_regulation (decrease) of HK2 associated with diabetes mellitus
2) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0.84 Pain Relevance 0

General Comments

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