INT277389

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Context Info
Confidence 0.61
First Reported 2009
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.87
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (SLC2A4) small molecule metabolic process (SLC2A4) plasma membrane (SLC2A4)
carbohydrate metabolic process (SLC2A4) transmembrane transport (SLC2A4) cytoplasm (SLC2A4)
Anatomy Link Frequency
muscle 2
adipocyte 2
SLC2A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 9 85.44 High High
cytokine 10 64.16 Quite High
tolerance 18 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
behavioral therapy 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 3 99.36 Very High Very High Very High
Hypertension 7 99.32 Very High Very High Very High
Diabetes Mellitus 219 97.24 Very High Very High Very High
Insulin Resistance 34 96.76 Very High Very High Very High
Obesity 152 95.84 Very High Very High Very High
Metabolic Syndrome 52 94.72 High High
Cardiovascular Disease 5 93.88 High High
INFLAMMATION 10 85.44 High High
Weight Loss 8 85.28 High High
Toxicity 2 81.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This observation can be explained by the fact that SLC2A4 expression is increased during a hyperinsulinemic clamp in healthy muscle but not in type 2 diabetic muscle [22].
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of SLC2A4 in muscle associated with diabetes mellitus
1) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0.49 Pain Relevance 0
An increase in the expression of proteins promoting efficient GLUT4 trafficking and fusion to the membrane (like VAMP2) could be a way to compensate for a decreased amount of GLUT4 protein.
Positive_regulation (increase) of Gene_expression (expression) of GLUT4
2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0.50 Pain Relevance 0
Similarly, additional experiments are necessary to clarify whether GLUT4 is directly regulated by RIP140 and what other transcriptional regulators are involved, or if altered GLUT4 expression is mediated through changes in adipocyte metabolism.
Spec (whether) Positive_regulation (mediated) of Gene_expression (expression) of GLUT4 in adipocyte
3) Confidence 0.32 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.56 Pain Relevance 0
Moreover, we have recently shown that maintenance of cellular mTOR function by anti-hypertensive drugs improves insulin signaling increasing GLUT 4 expression and prevents micro-vascular rarefaction in spontaneously hypertensive rats with insulin resistance.
Positive_regulation (increasing) of Gene_expression (expression) of GLUT 4 associated with hypertension and insulin resistance
4) Confidence 0.10 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.94 Pain Relevance 0.14
Increased insulin signaling activity, along with increases in GLUT-4 protein expression, may lead to increased GLUT-4 translocation thereby increasing glucose transport and reducing insulin-resistance.
Positive_regulation (increases) of Gene_expression (expression) of GLUT-4 protein associated with hyperinsulinism
5) Confidence 0.09 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 0.39 Pain Relevance 0

General Comments

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