INT27739

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Context Info
Confidence 0.70
First Reported 1989
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 49
Total Number 51
Disease Relevance 28.31
Pain Relevance 13.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EGF) extracellular space (EGF) extracellular region (EGF)
plasma membrane (EGF)
Anatomy Link Frequency
epithelial cell 3
urine 3
HGF 2
finger 1
platelet 1
EGF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 391 100.00 Very High Very High Very High
Inflammation 256 100.00 Very High Very High Very High
sodium channel 492 99.96 Very High Very High Very High
tetrodotoxin 140 99.84 Very High Very High Very High
agonist 63 99.80 Very High Very High Very High
Nav1.7 78 99.76 Very High Very High Very High
rheumatoid arthritis 90 99.44 Very High Very High Very High
interstitial cystitis 212 99.40 Very High Very High Very High
substance P 27 99.10 Very High Very High Very High
anesthesia 36 96.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 301 100.00 Very High Very High Very High
Atherosclerosis 2 99.72 Very High Very High Very High
Glioma 13 99.68 Very High Very High Very High
Ulcers 68 99.64 Very High Very High Very High
Cancer 328 99.60 Very High Very High Very High
Bordatella Infection 6 99.56 Very High Very High Very High
Rheumatoid Arthritis 94 99.44 Very High Very High Very High
Eye Disease 65 99.42 Very High Very High Very High
Interstitial Cystitis 212 99.40 Very High Very High Very High
Prostate Cancer 57 99.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adaptation may be associated with an increase in salivary EGF output.


Positive_regulation (increase) of EGF
1) Confidence 0.70 Published 1998 Journal Scand. J. Gastroenterol. Section Body Doc Link 9754723 Disease Relevance 0.07 Pain Relevance 0
EGF levels did not increase during intermittent androgen ablation.
Neg (not) Positive_regulation (increase) of EGF
2) Confidence 0.69 Published 2004 Journal Prostate Section Body Doc Link 15065088 Disease Relevance 0.06 Pain Relevance 0
Substance P induced biosynthesis of the zinc finger transcription factor Egr-1 in human glioma cells requires activation of the epidermal growth factor receptor and of extracellular signal-regulated protein kinase.
Positive_regulation (activation) of epidermal growth factor in finger associated with glioma and substance p
3) Confidence 0.64 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 12384223 Disease Relevance 0.55 Pain Relevance 0.47
Moreover, we show that the signaling cascade initiated by substance P or EGF are indistinguishable, including the activation of the EGF receptor, the activation of ERK, and the final stimulation of Egr-1 biosynthesis.
Positive_regulation (activation) of EGF associated with substance p
4) Confidence 0.64 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12384223 Disease Relevance 0.40 Pain Relevance 0.48
These results indicate that transactivation of the EGF receptor as well as stimulation of the mitogen activated/extracellular signal-regulated protein kinase (ERK) are essential for substance P/NK-1 receptor-induced activation of Egr-1 biosynthesis.
Positive_regulation (transactivation) of EGF associated with substance p
5) Confidence 0.64 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12384223 Disease Relevance 0.47 Pain Relevance 0.50
We previously determined that the urine of interstitial cystitis (IC) patients specifically contains a factor (antiproliferative factor [APF]) that inhibits primary bladder epithelial cell proliferation, and that it has significantly decreased levels of heparin-binding epidermal growth factor-like growth factor (HB-EGF) and increased levels of epidermal growth factor (EGF) compared with urine from asymptomatic controls and patients with bacterial cystitis.
Positive_regulation (increased) of EGF in epithelial cell associated with cystitis and interstitial cystitis
6) Confidence 0.63 Published 2001 Journal Urology Section Abstract Doc Link 11378043 Disease Relevance 1.13 Pain Relevance 0.46
A similar action of EGF on trophoblast proliferation has been reported in the horse, where in situ hybridisation has demonstrated that the concentration of mRNA encoding EGF increases in the glandular epithelial cells during early pregnancy, except in areas of intense lymphocytic infiltration into the decidua.
Positive_regulation (increases) of EGF in glandular epithelial cells
7) Confidence 0.54 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0.07 Pain Relevance 0
In addition, the receptor-mediated JNK activation was dependent on Src family tyrosine kinases, but independent of phosphatidylinositol-3 kinase and EGF receptor tyrosine kinases.
Neg (independent) Positive_regulation (independent) of EGF
8) Confidence 0.49 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12558970 Disease Relevance 0.20 Pain Relevance 0.48
In fact, recently published in vitro experiments show that Src family kinases are highly activated in cetuximab-resistant cells and that they enhance EGF-R activation despite the cetuximab-bound receptor.
Positive_regulation (activation) of EGF-R
9) Confidence 0.48 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2868849 Disease Relevance 0.61 Pain Relevance 0
METHODS: To investigate the effect of lidocaine (4 microM-40 mM) on epidermal growth factor (EGF)-stimulated autophosphorylation of EGFR, the authors studied purified EGFR in microtubes.
Spec (investigate) Positive_regulation (-stimulated) of epidermal growth factor
10) Confidence 0.48 Published 2004 Journal Anesthesiology Section Body Doc Link 15114219 Disease Relevance 0 Pain Relevance 0
METHODS: To investigate the effect of lidocaine (4 microM-40 mM) on epidermal growth factor (EGF)-stimulated autophosphorylation of EGFR, the authors studied purified EGFR in microtubes.
Spec (investigate) Positive_regulation (-stimulated) of EGF
11) Confidence 0.48 Published 2004 Journal Anesthesiology Section Body Doc Link 15114219 Disease Relevance 0 Pain Relevance 0
In the case of migration and endocytosis, there was a strong blocking effect of TTX on the EGF-induced enhancement; thus, for TTX vs EGF + TTX, P = 0.23 (migration) and P = 0.12 (endocytosis), ie EGF had no effect in the presence of TTX.
Positive_regulation (enhancement) of EGF-induced associated with tetrodotoxin
12) Confidence 0.47 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0 Pain Relevance 0.99
EGF-induced upregulation of VGSC activity has been shown previously in PC12 cells [17], and, more recently, in Mat-Lylu strongly metastatic rat PCa cells [19].
Positive_regulation (upregulation) of EGF-induced associated with sodium channel and reprotox - general 1
13) Confidence 0.47 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.55 Pain Relevance 0.37
Although blocking VGSC activity with TTX suppressed EGF-induced enhancement of endocytosis and migration, the statistical analysis suggested that the involvement of VGSC in invasion was somewhat less.
Positive_regulation (enhancement) of EGF-induced associated with tetrodotoxin and sodium channel
14) Confidence 0.47 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.35 Pain Relevance 0.55
We previously determined that the urine of interstitial cystitis (IC) patients specifically contains a factor (antiproliferative factor [APF]) that inhibits primary bladder epithelial cell proliferation, and that it has significantly decreased levels of heparin-binding epidermal growth factor-like growth factor (HB-EGF) and increased levels of epidermal growth factor (EGF) compared with urine from asymptomatic controls and patients with bacterial cystitis.
Positive_regulation (increased) of EGF in epithelial cell associated with cystitis and interstitial cystitis
15) Confidence 0.46 Published 2001 Journal Urology Section Abstract Doc Link 11378043 Disease Relevance 1.04 Pain Relevance 0.45
Base-line salivary EGF output was similar in all groups but increased in the placebo/ranitidine group on day 3 and in the ranitidine group on day 9.
Positive_regulation (increased) of EGF
16) Confidence 0.44 Published 1998 Journal Scand. J. Gastroenterol. Section Body Doc Link 9754723 Disease Relevance 0.08 Pain Relevance 0
EGF increased VGSC Nav1.7 (predominant isoform in PCa) mRNA and protein expressions.
Positive_regulation (increased) of EGF associated with sodium channel, nav1.7 and reprotox - general 1
17) Confidence 0.44 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC2211503 Disease Relevance 0.45 Pain Relevance 0.53
In fact, the biology of the VGSC (in being upregulated by growth factors, such as EGF, and enhancing various MCBs) is consistent with it being an early event in progression of PCa to metastasis.
Positive_regulation (upregulated) of EGF associated with sodium channel, metastasis and reprotox - general 1
18) Confidence 0.44 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.72 Pain Relevance 0.64
Interestingly, in both assays, increasing the EGF concentration ultimately produced reduced effects (Fig. 2B &2D).
Positive_regulation (increasing) of EGF
19) Confidence 0.44 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0 Pain Relevance 0.09
We previously determined that the urine of interstitial cystitis (IC) patients specifically contains a factor (antiproliferative factor [APF]) that inhibits primary bladder epithelial cell proliferation, and that it has significantly decreased levels of heparin-binding epidermal growth factor-like growth factor (HB-EGF) and increased levels of epidermal growth factor (EGF) compared with urine from asymptomatic controls and patients with bacterial cystitis.
Positive_regulation (increased) of epidermal growth factor in epithelial cell associated with cystitis and interstitial cystitis
20) Confidence 0.43 Published 2001 Journal Urology Section Abstract Doc Link 11378043 Disease Relevance 1.12 Pain Relevance 0.46

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