INT277397

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Context Info
Confidence 0.65
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.23
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (KIF1B) ATPase activity (KIF1B) cytoskeleton (KIF1B)
cytoskeleton-dependent intracellular transport (KIF1B) cytoplasm (KIF1B)
KIF1B (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 249 99.72 Very High Very High Very High
Insulin Resistance 36 99.32 Very High Very High Very High
Obesity 12 94.48 High High
Disease 27 90.64 High High
Muscle Weakness 3 70.08 Quite High
Frailty 6 8.00 Low Low
Appetite Loss 3 5.28 Low Low
Toxicity 3 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the expression of KIF1B was downregulated in the ‘D’ group using both the microarray and the qRT-PCR approach.
Gene_expression (expression) of KIF1B
1) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0.67 Pain Relevance 0
On the individual gene level, 11 genes showed altered expression levels in first degree relatives compared to controls, among others KIF1B and GDF8 (myostatin).
Gene_expression (expression) of KIF1B
2) Confidence 0.65 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2719801 Disease Relevance 0.68 Pain Relevance 0
Furthermore, several potentially important genes regarding the underlying causes of insulin resistance and type 2 diabetes (for example KIF1B and GDF8) have been identified and shown to have different gene expression levels in healthy first degree relatives compared to controls.
Gene_expression (expression) of KIF1B associated with diabetes mellitus and insulin resistance
3) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0.88 Pain Relevance 0

General Comments

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