INT27740

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Context Info
Confidence 0.67
First Reported 1981
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 9.66
Pain Relevance 3.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (COX8A) mitochondrion (COX8A) small molecule metabolic process (COX8A)
Anatomy Link Frequency
endothelial cells 2
blood 1
neurons 1
lutein cells 1
platelets 1
COX8A (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 3 100.00 Very High Very High Very High
Abeta 4 99.98 Very High Very High Very High
Locus ceruleus 11 99.38 Very High Very High Very High
headache 4 99.02 Very High Very High Very High
Morphine 7 98.08 Very High Very High Very High
analgesia 4 96.42 Very High Very High Very High
epidural 4 96.22 Very High Very High Very High
agonist 5 93.36 High High
opiate 9 93.00 High High
Calcium channel 1 92.16 High High
Disease Link Frequency Relevance Heat
Cancer 19 99.98 Very High Very High Very High
Coagulation Disorder 19 99.40 Very High Very High Very High
Disease 10 98.44 Very High Very High Very High
Cyst 2 97.64 Very High Very High Very High
Malignant Neoplastic Disease 9 96.00 Very High Very High Very High
Lymphangioma 3 95.52 Very High Very High Very High
Hepatitis 2 95.34 Very High Very High Very High
Syndrome 5 94.92 High High
Immunodeficiency 2 94.74 High High
Hemorrhage 13 93.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increases in the level of F.VIII:C of about four times the resting value can be expected both in hemophilia and von Willebrand disease, but it must be borne in mind that the range of individual responses is large.
Positive_regulation (Increases) of VIII associated with coagulation disorder and disease
1) Confidence 0.67 Published 1986 Journal Prog Hemost Thromb Section Abstract Doc Link 3104987 Disease Relevance 1.33 Pain Relevance 0
The between-centre CVs were high for both the VIII:C and vWF R:Ag assays.
Positive_regulation (high) of VIII
2) Confidence 0.49 Published 1989 Journal Thromb. Haemost. Section Abstract Doc Link 2665175 Disease Relevance 0.32 Pain Relevance 0.07
The cytoplasm of some of the atypical endothelial cells was immunohistochemically positive for vimentin, factor VIII-related antigen, CD 34, and thrombomodulin.
Positive_regulation (positive) of VIII in endothelial cells
3) Confidence 0.49 Published 1998 Journal Brain Tumor Pathol Section Abstract Doc Link 10328547 Disease Relevance 0.39 Pain Relevance 0.08
The tumor cells were all immunoreactive for vimentin, CD 34, and focally actin-positive in one case, but not for keratin, desmin, S-100 protein, carcinoembryonic antigen, alpha 1-ACT and F VIII-related antigen, supported a primitive mesenchymal origin. p53 protein was expressed in two of the malignant cases.
Positive_regulation (immunoreactive) of VIII associated with malignant neoplastic disease and cancer
4) Confidence 0.49 Published 1999 Journal Lung Cancer Section Abstract Doc Link 10100146 Disease Relevance 2.38 Pain Relevance 0.12
In the present study, we first demonstrated that the morphine-induced increases in adenylyl cyclase and PKA activity in the LC are associated with selective increases in levels of immunoreactivity of types I and VIII adenylyl cyclase and of the catalytic and type II regulatory subunits of PKA.
Positive_regulation (increases) of VIII associated with locus ceruleus and morphine
5) Confidence 0.49 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9315909 Disease Relevance 0.14 Pain Relevance 0.87
Immunohystochemical stains of the endothelial cells were positive for VIII Factor and D2-40 that are specific for lymphatic endothelium, yielding the final diagnosis of a cystic spienic lymphangioma.
Positive_regulation (positive) of VIII in endothelial cells associated with lymphangioma
6) Confidence 0.49 Published 2009 Journal Rev Med Chil Section Abstract Doc Link 20361136 Disease Relevance 0.66 Pain Relevance 0.08
All 11 tumors stained for factor VIII-related antigen and Ulex europeus agglutinin.
Positive_regulation (stained) of VIII associated with cancer
7) Confidence 0.49 Published 1993 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 8333560 Disease Relevance 1.45 Pain Relevance 0.09
Epidural analgesia prevented the cortisol and glucose response to surgery, but did not influence the coagulation and fibrinolytic response to surgery, except for an inhibition of the postoperative increase in factor VIII antigen.
Positive_regulation (increase) of VIII associated with epidural and analgesia
8) Confidence 0.49 Published 1981 Journal Br J Surg Section Abstract Doc Link 7225737 Disease Relevance 0.15 Pain Relevance 0.56
Improved hemophilia A carrier detection by DDAVP stimulation of factor VIII.
Positive_regulation (stimulation) of VIII associated with coagulation disorder and headache
9) Confidence 0.49 Published 1984 Journal J. Pediatr. Section Title Doc Link 6425482 Disease Relevance 0.34 Pain Relevance 0.10
In vitro and in vivo studies showed the inactivation of VIII:C by anti-VIII:C was markedly non-linear.
Positive_regulation (inactivation) of VIII
10) Confidence 0.49 Published 1984 Journal Thromb. Haemost. Section Abstract Doc Link 6084319 Disease Relevance 0.73 Pain Relevance 0.11
It did not require serum complement or factor VIII-related antigen for binding to platelets.
Neg (not) Positive_regulation (require) of VIII in platelets
11) Confidence 0.49 Published 1985 Journal Blood Section Abstract Doc Link 4040409 Disease Relevance 0.47 Pain Relevance 0.19
At a time when the acquired immunodeficiency syndrome as well as hepatitis and other blood-borne diseases are a threat to patients with bleeding disorders who need treatment with blood products, it is rewarding to realize that a number of these patients can be safely and effectively treated with their own desmopressin-stimulated F.VIII:C and vWF.
Positive_regulation (desmopressin-stimulated) of VIII in blood associated with coagulation disorder, syndrome, disease, hepatitis and immunodeficiency
12) Confidence 0.49 Published 1986 Journal Prog Hemost Thromb Section Abstract Doc Link 3104987 Disease Relevance 0.92 Pain Relevance 0
These results indicate that subtypes adenylyl cyclase I, III and VIII, which are activated by calcium, and adenylyl cyclase V and VI, which are inhibited by calcium, are not dominant isoforms in granulosa-lutein cells.
Positive_regulation (activated) of VIII in lutein cells
13) Confidence 0.45 Published 2001 Journal Reproduction Section Abstract Doc Link 11226046 Disease Relevance 0 Pain Relevance 0.24
More recently, we showed that acute Gi/o- coupled receptor activation inhibits the activity of several AC isozymes, including Ca2+/calmodulin-stimulated AC-I and -VIII, whereas chronic receptor activation induces their superactivation.
Positive_regulation (activation) of VIII
14) Confidence 0.45 Published 2005 Journal J. Mol. Neurosci. Section Abstract Doc Link 16186630 Disease Relevance 0.08 Pain Relevance 0.21
However, independently of the method used to activate specific adenylyl cyclase isozymes, acute activation of the mu-opioid receptor inhibited the activity of adenylyl cyclases I, V, VI, and VIII, while types II, IV, and VII were stimulated and type III was not affected.
Positive_regulation (activation) of VIII associated with opioid receptor
15) Confidence 0.45 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9030567 Disease Relevance 0 Pain Relevance 0.27
This study demonstrated that extracellular Abeta accumulation and AT8-immunoreactivity within neurons are age-related phenomena in cats, and that they can occur concurrently.
Positive_regulation (accumulation) of AT8-immunoreactivity in neurons associated with abeta
16) Confidence 0.00 Published 2006 Journal J. Feline Med. Surg. Section Abstract Doc Link 16603401 Disease Relevance 0.28 Pain Relevance 0.23

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