INT277402

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Context Info
Confidence 0.48
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.67
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TCF7L2) nucleoplasm (TCF7L2) nucleus (TCF7L2)
DNA binding (TCF7L2) transcription factor binding (TCF7L2)
TCF7L2 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 166 96.40 Very High Very High Very High
Disease 18 85.60 High High
Insulin Resistance 24 45.28 Quite Low
Obesity 8 27.40 Quite Low
Frailty 4 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Muscle Weakness 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most speculatively, it seems logical that changes in a transcription factor like TCF7L2 will lead to altered expression of other genes and not TCF7L2 itself.
Gene_expression (expression) of TCF7L2
1) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0.89 Pain Relevance 0
This was validated by qRTPCR analysis for the gene TCF7L2 (Table 2 and 3), in which SNPs so far have shown the strongest link to increased risk of type 2 diabetes.
Gene_expression (analysis) of TCF7L2 associated with diabetes mellitus
2) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0.78 Pain Relevance 0

General Comments

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