INT277404

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Context Info
Confidence 0.62
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.29
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MSTN) growth (MSTN) extracellular region (MSTN)
cytoplasm (MSTN)
Anatomy Link Frequency
muscle 2
MSTN (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 2 98.12 Very High Very High Very High
Appetite Loss 2 97.72 Very High Very High Very High
Frailty 4 96.60 Very High Very High Very High
Diabetes Mellitus 166 94.24 High High
Insulin Resistance 24 92.00 High High
Disease 18 90.36 High High
Muscle Weakness 2 65.60 Quite High
Obesity 8 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finding GDF8 (myostatin) to be upregulated in healthy first degree relatives in this study suggests that this factor could play an initiating role in the muscle wasting observed in many diabetic patients and potentially in the development of insulin resistance in the prediabetic stage.
Positive_regulation (upregulated) of myostatin in muscle associated with diabetes mellitus, frailty and insulin resistance
1) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 1.14 Pain Relevance 0
Finding GDF8 (myostatin) to be upregulated in healthy first degree relatives in this study suggests that this factor could play an initiating role in the muscle wasting observed in many diabetic patients and potentially in the development of insulin resistance in the prediabetic stage.
Positive_regulation (upregulated) of GDF8 in muscle associated with diabetes mellitus, frailty and insulin resistance
2) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 1.15 Pain Relevance 0

General Comments

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