INT277427

Context Info Confidence 0.32 First Reported 2009 Last Reported 2009 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.47 Pain Relevance 0.03

cell proliferation (Gdnf) phosphatase activity (Ptpn2) extracellular space (Gdnf) extracellular region (Gdnf) endoplasmic reticulum (Ptpn2) nucleus (Ptpn2)

Ptpn2 (Mus musculus) Gdnf (Mus musculus)

Pain Link Frequency Relevance Heat Substantia nigra 6 61.04 agonist 13 5.00 antagonist 9 5.00 Nerve growth factor 5 5.00 cerebral cortex 4 5.00 Glutamate 3 5.00 midbrain 2 5.00 anesthesia 2 5.00 alcohol 2 5.00 Glutamate receptor 2 5.00

Disease Link Frequency Relevance Heat Parkinson's Disease 41 100.00 Gliosis 2 97.20 Toxicity 8 37.12 Disease 9 5.00 Parkinsonian Disorders 7 5.00 Targeted Disruption 5 5.00 Hypersensitivity 5 5.00 Sleep Disorders 2 5.00 Death 2 5.00 Ataxia 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

MPTP alone did not change GDNF levels at 1 day, but enhanced GDNF levels at 2 and 3 days, perhaps as a result of reactive gliosis (see above).

MPTP Neg (not) Positive_regulation (enhanced) of Gene_expression (levels) of GDNF associated with parkinson's disease and gliosis

1) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.47 Pain Relevance 0.03

General Comments

This test has worked.