INT277431

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Context Info
Confidence 0.18
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) signal transduction (Grm3)
extracellular region (Gdnf) plasma membrane (Grm3) intracellular (Grm3)
Anatomy Link Frequency
neurons 3
Grm3 (Mus musculus)
Gdnf (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 2 71.24 Quite High
agonist 13 69.36 Quite High
Nerve growth factor 5 38.96 Quite Low
Spinal cord 1 24.00 Low Low
antagonist 9 5.00 Very Low Very Low Very Low
Substantia nigra 6 5.00 Very Low Very Low Very Low
cerebral cortex 4 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 2 24.36 Low Low
Parkinson's Disease 41 11.04 Low Low
Disease 9 5.00 Very Low Very Low Very Low
Toxicity 8 5.00 Very Low Very Low Very Low
Parkinsonian Disorders 7 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Hypersensitivity 5 5.00 Very Low Very Low Very Low
Sleep Disorders 2 5.00 Very Low Very Low Very Low
Ataxia 2 5.00 Very Low Very Low Very Low
Gliosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using pure cultures of striatal neurons we could
               establish that activation of mGlu3 receptors enhanced GDNF production by stimulating
               the MAPK and the PI-3-K pathways. 
Positive_regulation (activation) of mGlu3 in neurons Positive_regulation (enhanced) of Gene_expression (production) of GDNF in neurons
1) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0 Pain Relevance 0.07

General Comments

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