INT277432

Context Info Confidence 0.29 First Reported 2009 Last Reported 2009 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 1.41 Pain Relevance 0.06

cell proliferation (Gdnf) phosphatase activity (Ptpn2) extracellular space (Gdnf) extracellular region (Gdnf) endoplasmic reticulum (Ptpn2) nucleus (Ptpn2)

Ptpn2 (Mus musculus) Gdnf (Mus musculus)

Pain Link Frequency Relevance Heat Substantia nigra 18 61.04 agonist 39 9.12 antagonist 27 5.00 Nerve growth factor 15 5.00 cerebral cortex 12 5.00 Glutamate 9 5.00 midbrain 6 5.00 anesthesia 6 5.00 alcohol 6 5.00 Glutamate receptor 6 5.00

Disease Link Frequency Relevance Heat Parkinson's Disease 123 100.00 Gliosis 6 96.92 Toxicity 24 55.84 Psychosis 3 6.88 Disease 27 5.00 Parkinsonian Disorders 21 5.00 Targeted Disruption 15 5.00 Hypersensitivity 15 5.00 Sleep Disorders 6 5.00 Death 6 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, the combination of LY379268 further enhanced the increase in GDNF levels induced by MPTP at 2 and 3 days (Fig. 8).

MPTP Positive_regulation (induced) of GDNF associated with parkinson's disease

1) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.47 Pain Relevance 0

MPTP alone did not change GDNF levels at 1 day, but enhanced GDNF levels at 2 and 3 days, perhaps as a result of reactive gliosis (see above).

MPTP Neg (not) Positive_regulation (enhanced) of GDNF associated with parkinson's disease and gliosis

2) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.47 Pain Relevance 0.03

Interestingly, the combination of LY379268 further enhanced the increase in GDNF levels induced by MPTP at 2 and 3 days (Fig. 8).

MPTP Positive_regulation (increase) of GDNF associated with parkinson's disease

3) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.47 Pain Relevance 0.03

General Comments

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