INT277432

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Context Info
Confidence 0.29
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.41
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) phosphatase activity (Ptpn2) extracellular space (Gdnf)
extracellular region (Gdnf) endoplasmic reticulum (Ptpn2) nucleus (Ptpn2)
Ptpn2 (Mus musculus)
Gdnf (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 18 61.04 Quite High
agonist 39 9.12 Low Low
antagonist 27 5.00 Very Low Very Low Very Low
Nerve growth factor 15 5.00 Very Low Very Low Very Low
cerebral cortex 12 5.00 Very Low Very Low Very Low
Glutamate 9 5.00 Very Low Very Low Very Low
midbrain 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Glutamate receptor 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 123 100.00 Very High Very High Very High
Gliosis 6 96.92 Very High Very High Very High
Toxicity 24 55.84 Quite High
Psychosis 3 6.88 Low Low
Disease 27 5.00 Very Low Very Low Very Low
Parkinsonian Disorders 21 5.00 Very Low Very Low Very Low
Targeted Disruption 15 5.00 Very Low Very Low Very Low
Hypersensitivity 15 5.00 Very Low Very Low Very Low
Sleep Disorders 6 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the
                   combination of LY379268 further enhanced the increase in GDNF levels induced by
                   MPTP at 2 and 3 days (Fig.
                   8). 
MPTP Positive_regulation (induced) of GDNF associated with parkinson's disease
1) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.47 Pain Relevance 0
MPTP
                   alone did not change GDNF levels at 1 day, but enhanced GDNF levels at 2 and 3
                   days, perhaps as a result of reactive gliosis (see above). 
MPTP Neg (not) Positive_regulation (enhanced) of GDNF associated with parkinson's disease and gliosis
2) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.47 Pain Relevance 0.03
Interestingly, the
                   combination of LY379268 further enhanced the increase in GDNF levels induced by
                   MPTP at 2 and 3 days (Fig.
                   8). 
MPTP Positive_regulation (increase) of GDNF associated with parkinson's disease
3) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.47 Pain Relevance 0.03

General Comments

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