INT277433

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.60
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
nucleus (Wibg) cytoplasm (Wibg)
Wibg (Mus musculus)
Gdnf (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 13 76.00 Quite High
Intracerebroventricular 1 74.52 Quite High
midbrain 2 59.96 Quite High
Spinal cord 1 33.48 Quite Low
antagonist 9 5.00 Very Low Very Low Very Low
Substantia nigra 6 5.00 Very Low Very Low Very Low
Nerve growth factor 5 5.00 Very Low Very Low Very Low
cerebral cortex 4 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 41 98.40 Very High Very High Very High
Toxicity 8 98.20 Very High Very High Very High
Disease 9 90.72 High High
Parkinsonian Disorders 7 67.32 Quite High
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Hypersensitivity 5 5.00 Very Low Very Low Very Low
Sleep Disorders 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Ataxia 2 5.00 Very Low Very Low Very Low
Gliosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, the orally
               active compound, PYM50028, which elevates striatal levels of GDNF, is protective
               against MPTP toxicity in mice [47], and induction of GDNF is associated with the
               neurorescue action of rasagilin, a drug of current use in the treatment of
               Parkinson's disease [48], [49]. 
PYM50028 Positive_regulation (elevates) of GDNF associated with parkinson's disease, toxicity and disease
1) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.60 Pain Relevance 0.13

General Comments

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