INT277462

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Context Info
Confidence 0.09
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.23
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) oxidoreductase activity (Th)
nucleus (Th) cytoplasm (Th)
Th (Mus musculus)
Pain Link Frequency Relevance Heat
monoamine 1 99.56 Very High Very High Very High
midbrain 22 94.40 High High
Dopamine 94 92.00 High High
Catecholamine 2 89.16 High High
Glutamate 5 5.00 Very Low Very Low Very Low
gABA 4 5.00 Very Low Very Low Very Low
Action potential 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Substantia nigra 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 14 77.48 Quite High
Stress 17 76.56 Quite High
Drug Induced Neurotoxicity 2 76.32 Quite High
Disease 91 50.00 Quite Low
Parkinson's Disease 50 35.68 Quite Low
Neurodegenerative Disease 11 27.32 Quite Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Toxicity 7 5.00 Very Low Very Low Very Low
Apoptosis 7 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further characterize the role of the five candidate molecules in TH+ cell induction, EB cultures were exposed to various combinations of inducing factors followed by immunocytochemical marker analysis after 10 days of differentiation.
Regulation (role) of Positive_regulation (induction) of TH
1) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.14
It is also suggested that alpha-synuclein may modulate the activation of tyrosine hydroxylase (Perez et al., 2002) and down-regulate vesicular monoamine transporter-2 activity (Guo et al., 2008).
Regulation (regulate) of Positive_regulation (activation) of tyrosine hydroxylase associated with monoamine
2) Confidence 0.03 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.23 Pain Relevance 0.17

General Comments

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