INT277463

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Context Info
Confidence 0.23
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.64
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sfrp1) intracellular (Sfrp1) cytoplasm (Sfrp1)
cytosol (Sfrp1) extracellular space (Sfrp1) extracellular region (Sfrp1)
Anatomy Link Frequency
trabecular bone 1
midbrain 1
Sfrp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 83 99.36 Very High Very High Very High
midbrain 21 96.60 Very High Very High Very High
Osteoarthritis 1 72.12 Quite High
antagonist 3 50.00 Quite Low
Substantia nigra 1 16.40 Low Low
Serotonin 7 5.00 Very Low Very Low Very Low
Action potential 4 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 7 93.64 High High
Stomach Cancer 1 75.04 Quite High
Osteoarthritis 1 72.12 Quite High
Multiple Myeloma 1 71.36 Quite High
Disease 10 70.36 Quite High
Cervical Cancer 1 68.32 Quite High
Osteoporosis 10 56.64 Quite High
Bone Cancer 6 44.92 Quite Low
Congenital Anomalies 4 28.44 Quite Low
Cancer 5 27.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To date, sFRP-1 has been shown to be involved in the anabolic affects of PTH; deletion of sFRP-1 resulted in increased trabecular bone mineral density in a mouse model [95, 96].
Localization (deletion) of sFRP-1 in trabecular bone
1) Confidence 0.23 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.47 Pain Relevance 0.04
It should also be noted that we detected significantly higher levels of the soluble Wnt inhibitor secreted Frizzled-related protein 1(sFRP-1) in PA6-DA cells, which is suggested to have an inhibitory effect on ventral midbrain neuronal development (Z-ratio>14) than sFRP-2, which promotes DA neurogenesis and maturation (Z-ratio>3) [71].
Localization (secreted) of Frizzled-related protein 1 in midbrain associated with dopamine, midbrain and neurodegenerative disease
2) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0.16 Pain Relevance 0.32

General Comments

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