INT277465

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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.43
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf8) extracellular space (Fgf8) extracellular region (Fgf8)
Anatomy Link Frequency
embryos 4
mesoderm 2
Fgf8 (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 24 94.00 High High
Dopamine 83 91.24 High High
chemokine 2 68.72 Quite High
Action potential 4 9.28 Low Low
imagery 5 7.20 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
vagus nerve 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 56 85.56 High High
Nervous System Malformation 1 80.52 Quite High
Neurodegenerative Disease 7 74.56 Quite High
Congenital Anomalies 14 68.56 Quite High
Apoptosis 38 5.00 Very Low Very Low Very Low
Cleft Palate 16 5.00 Very Low Very Low Very Low
Ventricular Heart Septal Defects 8 5.00 Very Low Very Low Very Low
Persistent Truncus Arteriosus 8 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether fgf8 expression was altered in Spry1;Wnt1-Cre embryos through a cell non-autonomous mechanism, we performed whole mount in situ hybridization with an fgf8 riboprobe (Figure 7).
Spec (whether) Regulation (altered) of Spec (whether) Gene_expression (expression) of fgf8 in embryos
1) Confidence 0.25 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.15 Pain Relevance 0.03
This data rules out the possibility that changes in fgf8 expression or availability account for the decrease in proliferation seen in the first arch of Spry1;Wnt1-Cre embryos (Figure 5C).


Regulation (changes) of Gene_expression (expression) of fgf8 in embryos
2) Confidence 0.25 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.12 Pain Relevance 0.05
Nonetheless the introduction of FGF10 to chick embryos up-regulated FGF8 expression in the ectoderm through Wnt3a signaling and stimulated SHH expression in the posterior mesoderm followed by outgrowth initiation of chick limb structures [48], [49].
Regulation (regulated) of Gene_expression (expression) of FGF8 in mesoderm
3) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0.16 Pain Relevance 0.35

General Comments

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