INT277472

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.14
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PTN) extracellular region (PTN) endoplasmic reticulum (PTN)
Anatomy Link Frequency
DA neurons 1
PTN (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 166 98.56 Very High Very High Very High
midbrain 40 71.92 Quite High
metalloproteinase 3 29.24 Quite Low
Action potential 10 5.00 Very Low Very Low Very Low
gABA 6 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dermal Scarring 48 99.48 Very High Very High Very High
Cognitive Disorder 4 81.84 Quite High
Keloid Scars 8 68.64 Quite High
Cancer 8 56.96 Quite High
Neurodegenerative Disease 14 55.44 Quite High
Apoptosis 3 51.52 Quite High
Injury 3 39.52 Quite Low
Disease 31 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 8 5.00 Very Low Very Low Very Low
Shock 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This last suggestion will need to be confirmed by future studies that examine the responses of F5 PTNs whose discharge is suppressed by action observation, during performance of other tasks requiring the withholding of a motor response.


Spec (examine) Positive_regulation (responses) of PTN
1) Confidence 0.49 Published 2009 Journal Neuron Section Body Doc Link PMC2862290 Disease Relevance 0.07 Pain Relevance 0
Finally, a striking finding of this study is the relatively high proportion of F5 PTNs tested that showed mirror-like activity.
Positive_regulation (proportion) of PTN
2) Confidence 0.49 Published 2009 Journal Neuron Section Body Doc Link PMC2862290 Disease Relevance 0.08 Pain Relevance 0
However, in our study, an approximate 8-fold significant upregulation (P = .041) was observed in keloid biopsies for PTN, which correlates to PTN upregulation reported in keloid biopsies by Chen et al17 and Hu et al13 by microarray analysis.
Positive_regulation (upregulation) of PTN associated with dermal scarring
3) Confidence 0.35 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.93 Pain Relevance 0
The combination of the four factors SDF-1, PTN, IGF2, and EFNB1 was therefore termed “SPIE”.
Positive_regulation (termed) of PTN
4) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.14
The four factors SDF-1, PTN, IGF2, and EFNB1 were sufficient to induce hESC to differentiate to DA neurons.


Positive_regulation (sufficient) of PTN in DA neurons associated with dopamine
5) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0.06 Pain Relevance 0.31

General Comments

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