INT277531

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.48
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
photoreceptor 2
Clrn1 (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retina Disease 72 99.94 Very High Very High Very High
Disease 18 98.82 Very High Very High Very High
Targeted Disruption 136 88.24 High High
Usher Syndrome 72 5.00 Very Low Very Low Very Low
Deafness 28 5.00 Very Low Very Low Very Low
Blindness 16 5.00 Very Low Very Low Very Low
Ganglion Cysts 8 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Hearing Impairment 4 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to all other known disease-causing mutations resulting in retinitis pigmentosa (RP), Clrn1 mRNA expression was restricted to the inner nuclear layer (INL) of the retina, and was undetectable in photoreceptor or retinal pigmented epithelial (RPE) cells.
Regulation (undetectable) of Transcription (expression) of Clrn1 in photoreceptor associated with disease and retina disease
1) Confidence 0.45 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0.79 Pain Relevance 0
Moreover, no amplification was apparent when the RT enzyme was omitted from the cDNA synthesis reaction, ensuring that positive amplification was due to Clrn1 mRNA expression and not genomic DNA contamination.


Regulation (due) of Transcription (expression) of Clrn1
2) Confidence 0.45 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0.69 Pain Relevance 0

General Comments

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