INT277539

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 5
Disease Relevance 4.04
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Hair 3
retina 1
inner ear 1
Clrn1 (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 15 5.00 Very Low Very Low Very Low
ketamine 10 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Glutamate 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Usher Syndrome 180 100.00 Very High Very High Very High
Disease 45 99.56 Very High Very High Very High
Blindness 40 98.08 Very High Very High Very High
Deafness 70 97.52 Very High Very High Very High
Hearing Impairment 10 89.60 High High
Targeted Disruption 340 86.56 High High
Night Blindness 10 81.96 Quite High
Retina Disease 180 80.20 Quite High
Ganglion Cysts 20 5.00 Very Low Very Low Very Low
Death 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the more differentiated central retina, a narrower band of Clrn1 ISH-positive cells (Figure 3I) is apparent, and some of these cells also stain positively for Sox9 (Figure 3J; red) and Glast (Figure 3J; green).
Positive_regulation (band) of Clrn1 in retina
1) Confidence 0.50 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0 Pain Relevance 0
Similar to other forms of USH, the mRNA coding for the protein responsible for USH type 3 (CLRN1) is expressed in cochlear hair cells of the inner ear.
Positive_regulation (responsible) of CLRN1 in inner ear associated with usher syndrome
2) Confidence 0.50 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2719914 Disease Relevance 1.44 Pain Relevance 0
CLRN1 Is Nonessential in the Mouse Retina but Is Required for Cochlear Hair Cell Development

Mutations in the CLRN1 gene cause Usher syndrome type 3 (USH3), a human disease characterized by progressive blindness and deafness.

Positive_regulation (cause) of CLRN1 in Hair associated with deafness, blindness, disease and usher syndrome
3) Confidence 0.50 Published 2009 Journal PLoS Genetics Section Title Doc Link PMC2719914 Disease Relevance 0.86 Pain Relevance 0
CLRN1 Is Nonessential in the Mouse Retina but Is Required for Cochlear Hair Cell Development

Mutations in the CLRN1 gene cause Usher syndrome type 3 (USH3), a human disease characterized by progressive blindness and deafness.

Positive_regulation (cause) of USH3 in Hair associated with deafness, blindness, disease and usher syndrome
4) Confidence 0.50 Published 2009 Journal PLoS Genetics Section Title Doc Link PMC2719914 Disease Relevance 0.87 Pain Relevance 0
CLRN1 Is Nonessential in the Mouse Retina but Is Required for Cochlear Hair Cell Development

Mutations in the CLRN1 gene cause Usher syndrome type 3 (USH3), a human disease characterized by progressive blindness and deafness.

Positive_regulation (cause) of Usher syndrome type 3 in Hair associated with deafness, blindness, disease and usher syndrome
5) Confidence 0.44 Published 2009 Journal PLoS Genetics Section Title Doc Link PMC2719914 Disease Relevance 0.87 Pain Relevance 0

General Comments

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