INT27754

Context Info Confidence 0.52 First Reported 1989 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 7 Total Number 8 Disease Relevance 6.59 Pain Relevance 0.74

Anatomy Link Frequency spleen 1 respiratory 1 D19Mit9 (Mus musculus)

Pain Link Frequency Relevance Heat Chronic pancreatitis 2 95.80 Pain 4 94.80 abdominal pain 1 93.24 Bile 2 83.04 palliative 1 69.20

Disease Link Frequency Relevance Heat Cancer 17 100.00 Carcinoma 5 99.88 Cyst 16 99.68 Disease 5 99.56 Bronchogenic Cyst 2 98.68 Pancreatitis 6 97.76 Pancreatic Cancer 16 97.44 Bronchopulmonary Sequestration 8 96.84 Pain 4 94.80 Abdominal Pain 1 93.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The preoperative serum CA 19-9 level was increased (2 900 IU/mL).

Positive_regulation (increased) of 19-9

1) Confidence 0.52 Published 2007 Journal Minerva Chir Section Abstract Doc Link 17287693 Disease Relevance 0.37 Pain Relevance 0.09

The common embryogenic origin of both respiratory and digestive apparatus can explain the increased levels of tumor markers such as CA 19-9 and carcinoembryonic antigen in bronchogenic cyst, intestinal duplication and pulmonary sequestration.

Positive_regulation (increased) of 19-9 in respiratory associated with bronchogenic cyst, bronchopulmonary sequestration and cancer

2) Confidence 0.38 Published 2007 Journal Minerva Chir Section Abstract Doc Link 17287693 Disease Relevance 0.70 Pain Relevance 0.06

This is the first case reported in the literature of a true benign splenic cyst producing high levels of CEA and CA 19-9 in serum and cystic fluid.

Positive_regulation (levels) of 19-9 associated with cyst

3) Confidence 0.02 Published 1998 Journal Am Surg Section Abstract Doc Link 9843333 Disease Relevance 0.61 Pain Relevance 0.07

Laparoscopic resection of a benign true cyst of the spleen with the harmonic scalpel producing high levels of CA 19-9 and carcinoembryonic antigen.

Positive_regulation (levels) of 19-9 in spleen associated with cyst

4) Confidence 0.02 Published 1998 Journal Am Surg Section Title Doc Link 9843333 Disease Relevance 0.68 Pain Relevance 0.09

Analyses of preoperative and one to seven day postoperative determinations of CA 19-9, carcinoembryonic antigen (CEA) and CA 125 levels in 873 patients indicate that postoperative CA 19-9 and CEA serum levels were within the expected technical variance of the preoperative assay values in patients who were considered to have negative findings (below the reference value) from these tests preoperatively.

Positive_regulation (postoperative) of 19-9

5) Confidence 0.01 Published 1989 Journal Surg Gynecol Obstet Section Abstract Doc Link 2711294 Disease Relevance 0.29 Pain Relevance 0.07

Also 50-65% of patients with small resectable carcinomas have elevated CA 19-9 and CA 50 levels, although very high serum concentrations usually indicate advanced disease.

Positive_regulation (elevated) of 19-9 associated with carcinoma and disease

6) Confidence 0.01 Published 1989 Journal Ann Chir Gynaecol Section Abstract Doc Link 2667448 Disease Relevance 1.62 Pain Relevance 0.12

Serum CA 19-9 was elevated to 108 U/ml with normal carcinoembryonic antigen (CEA) and alpha-fetoprotein (AFP) levels.

Positive_regulation (elevated) of 19-9

7) Confidence 0.01 Published 1996 Journal J. Gastroenterol. Section Abstract Doc Link 8887044 Disease Relevance 0.67 Pain Relevance 0.09

Slightly elevated serum CA 19-9 and CA 50 levels are seen in some patients with benign pancreatic diseases, more often in acute than in chronic pancreatitis.

Positive_regulation (elevated) of 19-9 associated with pancreatitis and chronic pancreatitis

8) Confidence 0.01 Published 1989 Journal Ann Chir Gynaecol Section Abstract Doc Link 2667448 Disease Relevance 1.64 Pain Relevance 0.14

General Comments

This test has worked.