INT277550

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.50
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Gm14374) cellular_component (Gm14374) biological_process (Gm14374)
Anatomy Link Frequency
pyramidal cell 1
inner ear 1
Gm14374 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 59 99.68 Very High Very High Very High
Hippocampus 13 98.36 Very High Very High Very High
ketamine 77 78.44 Quite High
anesthesia 12 62.00 Quite High
Limbic system 4 44.48 Quite Low
interneuron 4 5.00 Very Low Very Low Very Low
medulla 3 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 2 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Usher Syndrome 36 100.00 Very High Very High Very High
Hearing Impairment 2 89.60 High High
Disease 9 89.52 High High
Blindness 8 88.68 High High
Deafness 14 84.04 Quite High
Night Blindness 2 81.96 Quite High
Targeted Disruption 68 72.72 Quite High
Retina Disease 36 72.04 Quite High
Unconsciousness 14 60.96 Quite High
Ganglion Cysts 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar to other forms of USH, the mRNA coding for the protein responsible for USH type 3 (CLRN1) is expressed in cochlear hair cells of the inner ear.
Positive_regulation (responsible) of type 3 in inner ear associated with usher syndrome
1) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2719914 Disease Relevance 1.43 Pain Relevance 0
Type-1 (basket cell), type-2 (bistratified cell) and type-3 (chandelier cell) are positioned in the pyramidal cell body layer in the hippocampus CA1 subregion.
Positive_regulation (positioned) of type-3 in pyramidal cell associated with pyramidal cell and hippocampus
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999569 Disease Relevance 0.06 Pain Relevance 0.42

General Comments

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