INT277552

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 0.75
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cilium (Whrn) cytoplasm (Whrn)
Anatomy Link Frequency
erythrocytes 1
Whrn (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 15 77.80 Quite High
Inflammation 6 32.08 Quite Low
ketamine 8 5.00 Very Low Very Low Very Low
analgesia 6 5.00 Very Low Very Low Very Low
Mechanotransduction 6 5.00 Very Low Very Low Very Low
TRP channel 6 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Usher Syndrome 36 94.36 High High
Deafness 26 92.72 High High
Targeted Disruption 110 88.00 High High
Hemorrhage 6 65.60 Quite High
Stress 12 54.48 Quite High
Ganglion Cysts 4 47.80 Quite Low
Blindness 8 32.80 Quite Low
Aging 6 32.80 Quite Low
INFLAMMATION 6 32.08 Quite Low
Wound Healing 6 30.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whirlin interacts with p55 which is expressed exclusively in outer hair cells (OHC) in both the long stereocilia that make up the stereocilia bundle proper as well as the shorter microvilli that will eventually regress. p55 interacts with protein 4.1R in erythrocytes [12], and 4.1R is also expressed in stereocilia with an identical pattern to p55.
Gene_expression (expressed) of Whirlin in erythrocytes
1) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.06 Pain Relevance 0
Whirlin is expressed at the stereocilia tip [5]–[7].
Gene_expression (expressed) of Whirlin
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.09 Pain Relevance 0
Gelsolin is also part of the whirlin interactome and is lost from stereocilia when the critical scaffold protein whirlin is absent or when proteins such as myosin XVa are absent which are important for trafficking whirlin to the stereocilia tip.
Neg (absent) Gene_expression (absent) of whirlin
3) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.28 Pain Relevance 0
Functional analysis of gelsolin in stereocilia using whirler and shaker2 mutants
Gene_expression (using) of whirler
4) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
Like p55, gelsolin is ablated in the whirler and shaker2 mutants.
Gene_expression (ablated) of whirler
5) Confidence 0.55 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
Epistasis of the whirler and gelsolin mutants
Gene_expression (mutants) of whirler
6) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.08 Pain Relevance 0.04
For example, whirlin, associated with mutations in USH2A [18], is expressed in the stereocilia and indeed Whrn mouse mutants have shorter stereocilia [66].
Gene_expression (expressed) of Whrn
7) Confidence 0.40 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0.24 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox